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Title: Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly
Authors: Zhang, L. 
Mak, E.
Reilhac, A. 
Shim, Hee Y.
Ng, K.K. 
Ong, M.Q.W.
Ji, F. 
Chong, E.J.Y.
Xu, X. 
Wong, Z.X.
Stephenson, M.C.
Venketasubramanian, N.
Tan, B.Y.
O'Brien, J.T.
Zhou, J.H.
Chen, C.L.H. 
Keywords: hippocampal subfield atrophy
longitudinal atrophy trajectory
nondemented elderly
Issue Date: 2020
Publisher: John Wiley and Sons Inc
Citation: Zhang, L., Mak, E., Reilhac, A., Shim, Hee Y., Ng, K.K., Ong, M.Q.W., Ji, F., Chong, E.J.Y., Xu, X., Wong, Z.X., Stephenson, M.C., Venketasubramanian, N., Tan, B.Y., O'Brien, J.T., Zhou, J.H., Chen, C.L.H. (2020). Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly. Human Brain Mapping 41 (8) : 2037-2047. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial 4.0 International
Abstract: Hippocampal atrophy and abnormal ?-Amyloid (A?) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of A?-associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated A? correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET-A? in AD-vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto-segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of A?-related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher A? correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal-to-widespread trajectory of A?-associated hippocampal subfield atrophy over disease progression in nondemented elderly. © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
Source Title: Human Brain Mapping
ISSN: 10659471
DOI: 10.1002/hbm.24928
Rights: Attribution-NonCommercial 4.0 International
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