Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13195-020-00734-y
Title: Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study
Authors: Röhr, S.
Pabst, A.
Riedel-Heller, S.G.
Jessen, F.
Turana, Y.
Handajani, Y.S.
Brayne, C.
Matthews, F.E.
Stephan, B.C.M.
Lipton, R.B.
Katz, M.J.
Wang, C.
Guerchet, M.
Preux, P.-M.
Mbelesso, P.
Ritchie, K.
Ancelin, M.-L.
Carrière, I.
Guaita, A.
Davin, A.
Vaccaro, R.
Kim, K.W.
Han, J.W.
Suh, S.W.
Shahar, S.
Din, N.C.
Vanoh, D.
van Boxtel, M.
Köhler, S.
Ganguli, M.
Jacobsen, E.P.
Snitz, B.E.
Anstey, K.J.
Cherbuin, N.
Kumagai, S.
Chen, S.
Narazaki, K.
Ng, T.P. 
Gao, Q. 
Gwee, X. 
Brodaty, H.
Kochan, N.A.
Trollor, J.
Lobo, A.
López-Antón, R.
Santabárbara, J.
Crawford, J.D.
Lipnicki, D.M.
Sachdev, P.S.
for Cohort Studies of Memory in an International Consortium (COSMIC).
Keywords: Cohort study
Data harmonization
Epidemiology
Individual participant data
Prevalence
Subjective cognitive decline
Issue Date: 2020
Publisher: BioMed Central Ltd
Citation: Röhr, S., Pabst, A., Riedel-Heller, S.G., Jessen, F., Turana, Y., Handajani, Y.S., Brayne, C., Matthews, F.E., Stephan, B.C.M., Lipton, R.B., Katz, M.J., Wang, C., Guerchet, M., Preux, P.-M., Mbelesso, P., Ritchie, K., Ancelin, M.-L., Carrière, I., Guaita, A., Davin, A., Vaccaro, R., Kim, K.W., Han, J.W., Suh, S.W., Shahar, S., Din, N.C., Vanoh, D., van Boxtel, M., Köhler, S., Ganguli, M., Jacobsen, E.P., Snitz, B.E., Anstey, K.J., Cherbuin, N., Kumagai, S., Chen, S., Narazaki, K., Ng, T.P., Gao, Q., Gwee, X., Brodaty, H., Kochan, N.A., Trollor, J., Lobo, A., López-Antón, R., Santabárbara, J., Crawford, J.D., Lipnicki, D.M., Sachdev, P.S., for Cohort Studies of Memory in an International Consortium (COSMIC). (2020). Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research and Therapy 12 (1) : 167. ScholarBank@NUS Repository. https://doi.org/10.1186/s13195-020-00734-y
Rights: Attribution 4.0 International
Abstract: Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results: The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3–24.4%) and IRT (25.6%, 95%CI = 25.1–26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1–7.0%, to 52.7%, 95%CI = 47.4–58.0%; IRT: 7.8%, 95%CI = 6.8–8.9%, to 52.7%, 95%CI = 47.4–58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field. © 2020, The Author(s).
Source Title: Alzheimer's Research and Therapy
URI: https://scholarbank.nus.edu.sg/handle/10635/196312
ISSN: 1758-9193
DOI: 10.1186/s13195-020-00734-y
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1186_s13195_020_00734_y.pdf743.29 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

16
checked on Aug 7, 2022

Page view(s)

79
checked on Aug 4, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons