Please use this identifier to cite or link to this item: https://doi.org/10.1111/cea.13993
Title: Atopic dermatitis trajectories to age 8 years in the GUSTO cohort
Authors: Noor H. A. Suaini
Gaik Chin Yap 
Bui Do Phuong Tung 
Evelyn Xiu Ling Loo 
Anne Eng Neo Goh 
Teoh Oon Hoe 
Kok Hian Tan 
Keith M. Godfrey
Bee Wah Lee 
Lynette Pei-chi Shek 
Hugo Van Bever 
Yap Seng Chong 
Elizabeth Huiwen Tham 
Keywords: atopic dermatitis
trajectories
wheezing
rhinitis
machine learning
Issue Date: 26-Jul-2021
Publisher: Wiley
Citation: Noor H. A. Suaini, Gaik Chin Yap, Bui Do Phuong Tung, Evelyn Xiu Ling Loo, Anne Eng Neo Goh, Teoh Oon Hoe, Kok Hian Tan, Keith M. Godfrey, Bee Wah Lee, Lynette Pei-chi Shek, Hugo Van Bever, Yap Seng Chong, Elizabeth Huiwen Tham (2021-07-26). Atopic dermatitis trajectories to age 8 years in the GUSTO cohort. Clinical and Experimental Allergy. ScholarBank@NUS Repository. https://doi.org/10.1111/cea.13993
Abstract: Background The heterogeneity of childhood atopic dermatitis (AD) underscores the need to understand latent phenotypes that may inform risk stratification and disease prognostication. Objective To identify AD trajectories across the first 8 years of life, investigate risk factors associated with each trajectory and their relationships with other comorbidities. Methods Data were collected prospectively from 1152 mother-offspring dyads in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort from ages 3 months to 8 years. AD was defined based on parent-reported doctor’s diagnosis. An unsupervised machine learning technique was used to determine AD trajectories. Results Three AD trajectories were identified: early onset transient (6.3%), late onset persistent (6.3%) and early onset persistent (2.1%), alongside a no AD/reference group (85.2%). Early onset transient AD was positively associated with male gender, family history of atopy, house dust mite sensitization and some measures of wheezing. Early onset persistent AD was associated with antenatal/intrapartum antibiotic use, food sensitization and some measures of wheezing. Late onset persistent AD was associated with a family history of atopy, some measures of house dust mite sensitization and some measures of allergic rhinitis and wheezing. Conclusion and Clinical Relevance Three AD trajectories were identified in this birth cohort, with different risk factors and prognostic implications. Further work is needed to understand the molecular and immunological origins of these phenotypes.
Source Title: Clinical and Experimental Allergy
URI: https://scholarbank.nus.edu.sg/handle/10635/195649
ISSN: 09547894
DOI: 10.1111/cea.13993
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GUSTO_AD_Trajectories_revised_V3.7_cleaned_090721.pdf219.22 kBAdobe PDF

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