Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroimage.2008.12.040
DC FieldValue
dc.titleRole of medial cortical, hippocampal and striatal interactions during cognitive set-shifting
dc.contributor.authorGraham, S.
dc.contributor.authorPhua, E.
dc.contributor.authorAu, C.
dc.contributor.authorSoon, C.S.
dc.contributor.authorOh, T.
dc.contributor.authorShuter, B.
dc.contributor.authorWang, S.-C.
dc.contributor.authorYeh, I.B.
dc.date.accessioned2011-02-23T02:52:13Z
dc.date.available2011-02-23T02:52:13Z
dc.date.issued2009
dc.identifier.citationGraham, S., Phua, E., Au, C., Soon, C.S., Oh, T., Shuter, B., Wang, S.-C., Yeh, I.B. (2009). Role of medial cortical, hippocampal and striatal interactions during cognitive set-shifting. NeuroImage 45 (4) : 1359-1367. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroimage.2008.12.040
dc.identifier.issn10538119
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/19553
dc.description.abstractTo date, few studies have examined the functional connectivity of brain regions involved in complex executive function tasks, such as cognitive set-shifting. In this study, eighteen healthy volunteers performed a cognitive set-shifting task modified from the Wisconsin card sort test while undergoing functional magnetic resonance imaging. These modifications allowed better disambiguation between cognitive processes and revealed several novel findings: 1) peak activation in the caudate nuclei in the first instance of negative feedback signaling a shift in rule, 2) lowest caudate activation once the rule had been identified, 3) peak hippocampal activation once the identity of the rule had been established, and 4) decreased hippocampal activation during the generation of new rule candidates. This pattern of activation across cognitive set-shifting events suggests that the caudate nuclei play a role in response generation when the identity of the new rule is unknown. In contrast, the reciprocal pattern of hippocampal activation suggests that the hippocampi help consolidate knowledge about the correct stimulus-stimulus associations, associations that become inappropriate once the rule has changed. Functional connectivity analysis using Granger Causality Mapping revealed that caudate and hippocampal regions interacted indirectly via a circuit involving the medial orbitofrontal and posterior cingulate regions, which are known to bias attention towards stimuli based on expectations built up from task-related feedback. Taken together, the evidence suggests that these medial regions may mediate striato-hippocampal interactions and hence affect goal-directed attentional transitions from a response strategy based on stimulus-reward heuristics (caudate-dependent) to one based on stimulus-stimulus associations (hippocampus-dependent). © 2008 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neuroimage.2008.12.040
dc.sourceScopus
dc.subjectCaudate
dc.subjectConnectivity
dc.subjectHippocampus
dc.subjectSet-shifting
dc.subjectWCST
dc.typeArticle
dc.contributor.departmentDIAGNOSTIC RADIOLOGY
dc.contributor.departmentPSYCHOLOGY
dc.description.doi10.1016/j.neuroimage.2008.12.040
dc.description.sourcetitleNeuroImage
dc.description.volume45
dc.description.issue4
dc.description.page1359-1367
dc.description.codenNEIME
dc.identifier.isiut000264378500031
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

42
checked on Nov 29, 2021

WEB OF SCIENCETM
Citations

41
checked on Nov 29, 2021

Page view(s)

272
checked on Dec 2, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.