Please use this identifier to cite or link to this item: https://doi.org/10.3390/polym13132075
Title: Fabrication of highly oriented cylindrical polyacrylonitrile, poly(Lactide-co-glycolide), polycaprolactone and poly(vinyl acetate) nanofibers for vascular graft applications
Authors: Malik, S
Sundarrajan, S 
Hussain, T
Nazir, A
Ramakrishna, S 
Keywords: cardiovascular diseases
collectors
cylindrical
mechanical strength
orientation
vascular grafts
Issue Date: 1-Jul-2021
Publisher: MDPI AG
Citation: Malik, S, Sundarrajan, S, Hussain, T, Nazir, A, Ramakrishna, S (2021-07-01). Fabrication of highly oriented cylindrical polyacrylonitrile, poly(Lactide-co-glycolide), polycaprolactone and poly(vinyl acetate) nanofibers for vascular graft applications. Polymers 13 (13) : 2075-2075. ScholarBank@NUS Repository. https://doi.org/10.3390/polym13132075
Abstract: Small-diameter vascular grafts fabricated from synthetic polymers have found limited applications so far in vascular surgeries, owing to their poor mechanical properties. In this study, cylindrical nanofibrous structures of highly oriented nanofibers made from polyacrylonitrile, poly (lactide-co-glycolide) (PLGA), polycaprolactone (PCL) and poly(vinyl acetate) (PVAc) were investigated. Cylindrical collectors with alternate conductive and non-conductive segments were used to obtain highly oriented nanofibrous structures at the same time with better mechanical properties. The surface morphology (orientation), mechanical properties and suture retention of the nanofibrous structures were characterized using SEM, mechanical tester and universal testing machine, respectively. The PLGA nanofibrous cylindrical structure exhibited excellent properties (tensile strength of 9.1 ± 0.6 MPa, suture retention strength of 27N and burst pressure of 350 ± 50 mmHg) when compared to other polymers. Moreover, the PLGA grafts showed good porosity and elongation values, that could be potentially used for vascular graft applications. The combination of PLGA nanofibers with extracellular vesicles (EVs) will be explored as a potential vascular graft in future.
Source Title: Polymers
URI: https://scholarbank.nus.edu.sg/handle/10635/194855
ISSN: 20734360
20734360
DOI: 10.3390/polym13132075
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