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Title: Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions
Authors: Joy-Immediato, Michelle
Ramirez, Manuel J
Cerda, Mauricio
Toyama, Yusuke 
Ravasio, Andrea 
Kanchanawong, Pakorn 
Bertocchi, Cristina 
Issue Date: Jun-2021
Publisher: Frontiers Media SA
Citation: Joy-Immediato, Michelle, Ramirez, Manuel J, Cerda, Mauricio, Toyama, Yusuke, Ravasio, Andrea, Kanchanawong, Pakorn, Bertocchi, Cristina (2021-06). Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions. Frontiers in Cell and Developmental Biology 9. ScholarBank@NUS Repository.
Abstract: Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact is well documented, little is known about the involvement of microtubules and the associated endoplasmic reticulum (ER) network in cadherin mechanotransduction. Therefore, we investigated how the organization of ER extensions in close proximity of cadherin-mediated adhesions can affect such complexes, and vice versa. Here, we show that the extension of the ER to cadherin-mediated adhesions is tension dependent and appears to be cadherin-type specific. Furthermore, the different structural organization of the ER/microtubule network seems to affect the localization of ER-bound PTP1B at cadherin-mediated adhesions. This phosphatase is involved in the modulation of vinculin, a molecular clutch which enables differential engagement of the cadherin-catenin layer with the actomyosin cytoskeleton in response to tension. This suggests a link between structural organization of the ER/microtubule network around cadherin-specific adhesions, to control the mechanotransduction of adherens junctions by modulation of vinculin conformational state.
Source Title: Frontiers in Cell and Developmental Biology
ISSN: 2296634X
DOI: 10.3389/fcell.2021.669086
Appears in Collections:Staff Publications

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