Please use this identifier to cite or link to this item: https://doi.org/10.1042/ETLS20180167
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dc.titleVisualizing the 'backbone' of focal adhesions
dc.contributor.authorBarnett, SFH
dc.contributor.authorKanchanawong, P
dc.date.accessioned2021-07-13T09:27:39Z
dc.date.available2021-07-13T09:27:39Z
dc.date.issued2018-12-01
dc.identifier.citationBarnett, SFH, Kanchanawong, P (2018-12-01). Visualizing the 'backbone' of focal adhesions. Emerging Topics in Life Sciences 2 (5) : 677-680. ScholarBank@NUS Repository. https://doi.org/10.1042/ETLS20180167
dc.identifier.issn23978554
dc.identifier.issn23978562
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/194057
dc.description.abstractTo understand how complex machines perform their functions, it is essential to map out the 'blueprints' of how their internal components are organized. Focal adhesions (FAs) are complex mechanobiological structures involved in a plethora of cell biological processes. The application of super-resolution microscopy in concert with protein engineering offers one approach to unravel the complexity of how individual proteins are organized within FAs. In our recent application, the FA protein talin was found to form a direct structural and physical link between integrin and actin. Interestingly, engineered talin constructs with alternate lengths rescaled the FA nanostructure accordingly. This helped establish that talin could be analogous to the backbone of FAs, serving as the mechanosensitive master coordinator of FA structural organization.
dc.publisherPortland Press Ltd.
dc.sourceElements
dc.subjectcell adhesion
dc.subjectcytoskeleton
dc.subjectsuper-resolution microscopy
dc.typeReview
dc.date.updated2021-07-13T08:11:42Z
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1042/ETLS20180167
dc.description.sourcetitleEmerging Topics in Life Sciences
dc.description.volume2
dc.description.issue5
dc.description.page677-680
dc.published.statePublished
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