Please use this identifier to cite or link to this item: https://doi.org/10.1042/ETLS20180167
Title: Visualizing the 'backbone' of focal adhesions
Authors: Barnett, SFH
Kanchanawong, P 
Keywords: cell adhesion
cytoskeleton
super-resolution microscopy
Issue Date: 1-Dec-2018
Publisher: Portland Press Ltd.
Citation: Barnett, SFH, Kanchanawong, P (2018-12-01). Visualizing the 'backbone' of focal adhesions. Emerging Topics in Life Sciences 2 (5) : 677-680. ScholarBank@NUS Repository. https://doi.org/10.1042/ETLS20180167
Abstract: To understand how complex machines perform their functions, it is essential to map out the 'blueprints' of how their internal components are organized. Focal adhesions (FAs) are complex mechanobiological structures involved in a plethora of cell biological processes. The application of super-resolution microscopy in concert with protein engineering offers one approach to unravel the complexity of how individual proteins are organized within FAs. In our recent application, the FA protein talin was found to form a direct structural and physical link between integrin and actin. Interestingly, engineered talin constructs with alternate lengths rescaled the FA nanostructure accordingly. This helped establish that talin could be analogous to the backbone of FAs, serving as the mechanosensitive master coordinator of FA structural organization.
Source Title: Emerging Topics in Life Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/194057
ISSN: 23978554
23978562
DOI: 10.1042/ETLS20180167
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