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Title: Identification of plant as a novel and alternative host model for Burkholderia pseudomallei
Keywords: Burkholderia pseudomallei, Burkholderia thailandensis, plant, Type Three Secretion System, model
Issue Date: 30-Mar-2009
Citation: LEE YIAN HOON (2009-03-30). Identification of plant as a novel and alternative host model for Burkholderia pseudomallei. ScholarBank@NUS Repository.
Abstract: Burkholderia pseudomallei is a Gram negative soil bacterium and the causative agent for melioidosis. The type three secretion system (TTSS) is important in the pathogenesis of B. pseudomallei in mammalian hosts. B. pseudomallei has three TTSS while B. thailandensis, a closely related but avirulent species, has two. Both bacteria share high homology in the TTSS2 locus with Ralstonia solanacearum, which causes bacterial wilt in various crops and plants. In this study, we demonstrated the ability of B. pseudomallei and B. thailandensis to infect tomato but not rice plants. Bacteria were found to multiply intercellularly and localize in the xylem vessels of the vascular bundle. Infection with KHWdeltaTTSS1 or KHWdeltaTTSS2 mutants shows substantial attenuation in disease, indicating their importance in bacterial pathogenesis in susceptible plants. The potential of B. pseudomallei as a plant pathogen raises new possibilities of exploiting plant as an alternative host for novel anti-infectives or virulence factor discovery.
Appears in Collections:Master's Theses (Open)

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