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Title: A study of alginate matrices as anti-microbial wound dressing
Keywords: Cross-linking cations, Additives, Functional properties, Anti-microbial properties, Cytotoxic properties, Alginate matrices
Issue Date: 3-Feb-2009
Citation: GOH CHEONG HIAN (2009-02-03). A study of alginate matrices as anti-microbial wound dressing. ScholarBank@NUS Repository.
Abstract: In this study, the effects of various cross-linking cations and additives on the functional, anti-microbial and cytotoxic properties of the alginate matrix were investigated using alginate pellets, films and fibres. The cross-linking cations influenced the morphology and anti-microbial activities of cross-linked alginate pellets with or without antimicrobial agents. These cations were generally compatible with common topical anti-microbial agents. Films cross-linked by different cations in the presence of Na+ exhibited differences in film thickness and weight, as well as content and release profile of specific cations. Their functional properties, such as mechanical strength, fluid uptake capacity and rate of degradation also varied. The additives, polyethylene glycol (PEG) 1500, PEG 6000, polyvinylpyrrolidone (PVP) C15 and PVP S630, were used to modify the functional properties and cytotoxicity of the alginate fibres developed. Copper alginate fibres with suitable characteristics for use in wound dressings could be achieved with the incorporation of suitable additives.
Appears in Collections:Ph.D Theses (Open)

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