Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/191714
DC Field | Value | |
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dc.title | THERAPEUTIC POTENTIAL OF ANTI-NA+/K+-ATPASE ANTIBODIES FOR PARKINSON’S DISEASE | |
dc.contributor.author | CAO LEI | |
dc.date.accessioned | 2021-05-31T18:00:43Z | |
dc.date.available | 2021-05-31T18:00:43Z | |
dc.date.issued | 2021-01-20 | |
dc.identifier.citation | CAO LEI (2021-01-20). THERAPEUTIC POTENTIAL OF ANTI-NA+/K+-ATPASE ANTIBODIES FOR PARKINSON’S DISEASE. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/191714 | |
dc.description.abstract | Na+/K+-ATPase (NKA) is identified as one of the P-type ATPase and is expressed ubiquitously in all cells. A progressive decline of NKA activity has been well recognized in the ageing process. More importantly, decreased NKA activity is also found in PD patients. Motor symptom of rapid-onset dystonia-Parkinsonism (RDP) and abnormal dopamine metabolites in cerebrospinal fluid exist in the patients harboring genetic mutation of ATP1A3. These findings imply that malfunction of NKA may play an important role in PD pathogenesis. Here, this study aims to: 1). investigate the role of NKA in PD pathogenesis, 2). evaluate the possibility of NKA as a therapeutic target for PD. Both 6-hydroxydopamine (6-OHDA)- and α-Synuclein preformed fibrils (PFF)- induced PD models were employed in this study. | |
dc.language.iso | en | |
dc.subject | Immunotherapy, Na/K-ATPase, Autophagy, Parkinson's disease, Oxidative stress, neurodegeneration | |
dc.type | Thesis | |
dc.contributor.department | PHARMACOLOGY | |
dc.contributor.supervisor | Gavin Stewart Dawe | |
dc.contributor.supervisor | Bian Jinsong | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY (SOM) | |
dc.identifier.orcid | 0000-0002-6493-1467 | |
Appears in Collections: | Ph.D Theses (Open) |
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Cao L-PhD Thesis.pdf | 5.04 MB | Adobe PDF | OPEN | None | View/Download |
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