|Title:||Ocular growth and metabolomics are dependent upon the spectral content of ambient white light||Authors:||Najjar, Raymond P
Chao De La Barca, Juan Manuel
Barathi, Veluchamy A
Ho, Candice Ee Hua
Lock, Jing Zhan
Muralidharan, Arumugam R
Tan, Royston KY
|Issue Date:||Dec-2021||Publisher:||Springer Science and Business Media LLC||Citation:||Najjar, Raymond P, Chao De La Barca, Juan Manuel, Barathi, Veluchamy A, Ho, Candice Ee Hua, Lock, Jing Zhan, Muralidharan, Arumugam R, Tan, Royston KY, Dhand, Chetna, Lakshminarayanan, Rajamani, Reynier, Pascal, Milea, Dan (2021-12). Ocular growth and metabolomics are dependent upon the spectral content of ambient white light. Scientific Reports 11 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-87201-2||Abstract:||
Myopia results from an excessive axial growth of the eye, causing abnormal projection of remote images in front of the retina. Without adequate interventions, myopia is forecasted to affect 50% of the world population by 2050. Exposure to outdoor light plays a critical role in preventing myopia in children, possibly through the brightness and blue-shifted spectral composition of sunlight, which lacks in artificial indoor lighting. Here, we evaluated the impact of moderate levels of ambient standard white (SW: 233.1 lux, 3900 K) and blue-enriched white (BEW: 223.8 lux, 9700 K) lights on ocular growth and metabolomics in a chicken-model of form-deprivation myopia. Compared to SW light, BEW light decreased aberrant ocular axial elongation and accelerated recovery from form-deprivation. Furthermore, the metabolomic profiles in the vitreous and retinas of recovering form-deprived eyes were distinct from control eyes and were dependent on the spectral content of ambient light. For instance, exposure to BEW light was associated with deep lipid remodeling and metabolic changes related to energy production, cell proliferation, collagen turnover and nitric oxide metabolism. This study provides new insight on light-dependent modulations in ocular growth and metabolomics. If replicable in humans, our findings open new potential avenues for spectrally-tailored light-therapy strategies for myopia.
|Source Title:||Scientific Reports||URI:||https://scholarbank.nus.edu.sg/handle/10635/189164||ISSN:||20452322||DOI:||10.1038/s41598-021-87201-2|
|Appears in Collections:||Staff Publications|
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|Najjar et al. 2021_SciRep_Spectrum of white light and ocular growth.pdf||Published version||3.47 MB||Adobe PDF|
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