Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-021-87201-2
Title: Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
Authors: Najjar, Raymond P 
Chao De La Barca, Juan Manuel
Barathi, Veluchamy A 
Ho, Candice Ee Hua
Lock, Jing Zhan
Muralidharan, Arumugam R
Tan, Royston KY 
Dhand, Chetna
Lakshminarayanan, Rajamani
Reynier, Pascal
Milea, Dan 
Issue Date: Dec-2021
Publisher: Springer Science and Business Media LLC
Citation: Najjar, Raymond P, Chao De La Barca, Juan Manuel, Barathi, Veluchamy A, Ho, Candice Ee Hua, Lock, Jing Zhan, Muralidharan, Arumugam R, Tan, Royston KY, Dhand, Chetna, Lakshminarayanan, Rajamani, Reynier, Pascal, Milea, Dan (2021-12). Ocular growth and metabolomics are dependent upon the spectral content of ambient white light. Scientific Reports 11 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-87201-2
Abstract: AbstractMyopia results from an excessive axial growth of the eye, causing abnormal projection of remote images in front of the retina. Without adequate interventions, myopia is forecasted to affect 50% of the world population by 2050. Exposure to outdoor light plays a critical role in preventing myopia in children, possibly through the brightness and blue-shifted spectral composition of sunlight, which lacks in artificial indoor lighting. Here, we evaluated the impact of moderate levels of ambient standard white (SW: 233.1 lux, 3900 K) and blue-enriched white (BEW: 223.8 lux, 9700 K) lights on ocular growth and metabolomics in a chicken-model of form-deprivation myopia. Compared to SW light, BEW light decreased aberrant ocular axial elongation and accelerated recovery from form-deprivation. Furthermore, the metabolomic profiles in the vitreous and retinas of recovering form-deprived eyes were distinct from control eyes and were dependent on the spectral content of ambient light. For instance, exposure to BEW light was associated with deep lipid remodeling and metabolic changes related to energy production, cell proliferation, collagen turnover and nitric oxide metabolism. This study provides new insight on light-dependent modulations in ocular growth and metabolomics. If replicable in humans, our findings open new potential avenues for spectrally-tailored light-therapy strategies for myopia.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/189164
ISSN: 20452322
DOI: 10.1038/s41598-021-87201-2
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