Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/189085
DC Field | Value | |
---|---|---|
dc.title | Biodegradable rare earth fluorochloride nanocrystals for phototheranostics | |
dc.contributor.author | Xinyu Zhao | |
dc.contributor.author | Qi Yu | |
dc.contributor.author | Jun Yuan | |
dc.contributor.author | Nitish V. Thakorb | |
dc.contributor.author | Mei Chee Tan | |
dc.date.accessioned | 2021-04-11T12:58:56Z | |
dc.date.available | 2021-04-11T12:58:56Z | |
dc.date.issued | 2020-04-13 | |
dc.identifier.citation | Xinyu Zhao, Qi Yu, Jun Yuan, Nitish V. Thakorb, Mei Chee Tan (2020-04-13). Biodegradable rare earth fluorochloride nanocrystals for phototheranostics. RSC Advances 26 : 15387–15393. ScholarBank@NUS Repository. | |
dc.identifier.issn | 20462069 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/189085 | |
dc.description.abstract | Rare earth (RE) doped inorganic nanocrystals have been demonstrated as efficient contrast agents for deep tissue shortwave-infrared (SWIR) imaging with high sensitivities leading to potential early detection of tumors. However, a potential concern is the unknown long-term toxicity and incompatibility of inorganic nanocrystals. In this work, biodegradable rare earth nanocrystals of Nd doped SrFCl coated with polydopamine (SrFCl:Nd@PDA) were designed. Instead of traditional fluoride hosts, the chlorinated SrF2 (i.e. SrFCl) with low phonon energy which significantly improved the brightness of SrFCl:Nd in the SWIR region was used as the host. After coating with a NIR-absorptive PDA layer, the SrFCl:Nd nanoparticles serve as not only a contrast agent for photoacoustic imaging, but also a potential photothermal agent for cancer therapy. Moreover, these SrFCl:Nd@PDA nanoparticles can be rapidly and completely degraded in phosphate buffer solution within 1 h, which effectively addresses the concerns of the deleterious effects arising from potential long term accumulation. The increased accumulation and retention at tumor sites, and complete in vivo clearance ?6 h after injection make these SrFCl:Nd@PDA nanoparticles a promising degradable phototheranostic agent. | |
dc.publisher | Royal Society of Chemistry | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.type | Article | |
dc.contributor.department | BIOMEDICAL ENGINEERING | |
dc.description.sourcetitle | RSC Advances | |
dc.description.volume | 26 | |
dc.description.page | 15387–15393 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Biodegradable rare earth fluorochloride nanocrystals for phototheranostics.pdf | 680.08 kB | Adobe PDF | OPEN | Published | View/Download |
Google ScholarTM
Check
This item is licensed under a Creative Commons License