Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.0c00672
Title: Nanotunnels within Poly(3,4-ethylenedioxythiophene)-Carbon Nanotube Composite for Highly Sensitive Neural Interfacing
Authors: Chen, Nuan 
Luo, Baiwen 
Patil, Anoop C 
Wang, Jiahui 
Gammad, Gil Gerald Lasam 
Yi, Zhigao 
Liu, Xiaogang 
Yen, Shih-Cheng 
Ramakrishna, Seeram 
Thakor, Nitish V 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
neural interface
nanostructured coating
conducting polymer
peripheral nervous system
sensory recoding
MICROPOROUS CONDUCTING POLYMERS
MICROELECTRODE ARRAYS
ELECTRICAL-PROPERTIES
NERVE CONDUCTION
ELECTRODES
STIMULATION
VELOCITY
SKIN
GOLD
ADHESION
Issue Date: 2020
Publisher: AMER CHEMICAL SOC
Citation: Chen, Nuan, Luo, Baiwen, Patil, Anoop C, Wang, Jiahui, Gammad, Gil Gerald Lasam, Yi, Zhigao, Liu, Xiaogang, Yen, Shih-Cheng, Ramakrishna, Seeram, Thakor, Nitish V (2020/07/28). Nanotunnels within Poly(3,4-ethylenedioxythiophene)-Carbon Nanotube Composite for Highly Sensitive Neural Interfacing. ACS NANO 14 (7) : 8059-8073. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.0c00672
Abstract: Neural electrodes are developed for direct communication with neural tissues for theranostics. Although various strategies have been employed to improve performance, creating an intimate electrode-tissue interface with high electrical fidelity remains a great challenge. Here, we report the rational design of a tunnel-like electrode coating comprising poly(3,4-ethylenedioxythiophene) (PEDOT) and carbon nanotubes (CNTs) for highly sensitive neural recording. The coated electrode shows a 50-fold reduction in electrochemical impedance at the biologically relevant frequency of 1 kHz, compared to the bare gold electrode. The incorporation of CNT significantly reinforces the nanotunnel structure and improves coating adhesion by â1.5 fold. In vitro primary neuron culture confirms an intimate contact between neurons and the PEDOT-CNT nanotunnel. During acute in vivo nerve recording, the coated electrode enables the capture of high-fidelity neural signals with low susceptibility to electrical noise and reveals the potential for precisely decoding sensory information through mechanical and thermal stimulation. These findings indicate that the PEDOT-CNT nanotunnel composite serves as an active interfacing material for neural electrodes, contributing to neural prosthesis and brain-machine interface.
Source Title: ACS NANO
URI: https://scholarbank.nus.edu.sg/handle/10635/188981
ISSN: 19360851
1936086X
DOI: 10.1021/acsnano.0c00672
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