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https://doi.org/10.1021/acsnano.0c00672
Title: | Nanotunnels within Poly(3,4-ethylenedioxythiophene)-Carbon Nanotube Composite for Highly Sensitive Neural Interfacing | Authors: | Chen, Nuan Luo, Baiwen Patil, Anoop C Wang, Jiahui Gammad, Gil Gerald Lasam Yi, Zhigao Liu, Xiaogang Yen, Shih-Cheng Ramakrishna, Seeram Thakor, Nitish V |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science neural interface nanostructured coating conducting polymer peripheral nervous system sensory recoding MICROPOROUS CONDUCTING POLYMERS MICROELECTRODE ARRAYS ELECTRICAL-PROPERTIES NERVE CONDUCTION ELECTRODES STIMULATION VELOCITY SKIN GOLD ADHESION |
Issue Date: | 2020 | Publisher: | AMER CHEMICAL SOC | Citation: | Chen, Nuan, Luo, Baiwen, Patil, Anoop C, Wang, Jiahui, Gammad, Gil Gerald Lasam, Yi, Zhigao, Liu, Xiaogang, Yen, Shih-Cheng, Ramakrishna, Seeram, Thakor, Nitish V (2020/07/28). Nanotunnels within Poly(3,4-ethylenedioxythiophene)-Carbon Nanotube Composite for Highly Sensitive Neural Interfacing. ACS NANO 14 (7) : 8059-8073. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.0c00672 | Abstract: | Neural electrodes are developed for direct communication with neural tissues for theranostics. Although various strategies have been employed to improve performance, creating an intimate electrode-tissue interface with high electrical fidelity remains a great challenge. Here, we report the rational design of a tunnel-like electrode coating comprising poly(3,4-ethylenedioxythiophene) (PEDOT) and carbon nanotubes (CNTs) for highly sensitive neural recording. The coated electrode shows a 50-fold reduction in electrochemical impedance at the biologically relevant frequency of 1 kHz, compared to the bare gold electrode. The incorporation of CNT significantly reinforces the nanotunnel structure and improves coating adhesion by â1.5 fold. In vitro primary neuron culture confirms an intimate contact between neurons and the PEDOT-CNT nanotunnel. During acute in vivo nerve recording, the coated electrode enables the capture of high-fidelity neural signals with low susceptibility to electrical noise and reveals the potential for precisely decoding sensory information through mechanical and thermal stimulation. These findings indicate that the PEDOT-CNT nanotunnel composite serves as an active interfacing material for neural electrodes, contributing to neural prosthesis and brain-machine interface. | Source Title: | ACS NANO | URI: | https://scholarbank.nus.edu.sg/handle/10635/188981 | ISSN: | 19360851 1936086X |
DOI: | 10.1021/acsnano.0c00672 |
Appears in Collections: | Staff Publications Elements |
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Revised Manuscript-20200529.docx | Submitted version | 9.74 MB | Microsoft Word XML | OPEN | None | View/Download |
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