Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.AC119.011795
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dc.titleCD137 negatively affects "browning" of white adipose tissue during cold exposure
dc.contributor.authorRAJ KAMAL SRIVASTAVA
dc.contributor.authorANNALENA IBANEZ MOLINER
dc.contributor.authorLEE EE SOO
dc.contributor.authorEMILY PAULINE NICKLES
dc.contributor.authorSIM WEILING EUNICE
dc.contributor.authorLIU CHANG
dc.contributor.authorSCHWARZ,HERBERT
dc.contributor.authorCARLOS F. IBANEZ
dc.date.accessioned2021-04-08T00:52:13Z
dc.date.available2021-04-08T00:52:13Z
dc.date.issued2020-02-14
dc.identifier.citationRAJ KAMAL SRIVASTAVA, ANNALENA IBANEZ MOLINER, LEE EE SOO, EMILY PAULINE NICKLES, SIM WEILING EUNICE, LIU CHANG, SCHWARZ,HERBERT, CARLOS F. IBANEZ (2020-02-14). CD137 negatively affects "browning" of white adipose tissue during cold exposure. JOURNAL OF BIOLOGICAL CHEMISTRY 295 (7) : 2034-2042. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.AC119.011795
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/188720
dc.description.abstractProlonged cold exposure stimulates the formation of brown-like adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical brown adipose tissue, contributes to maintaining body temperature in mammals through nonshivering thermogenesis. The mechanisms that regulate the formation of these cells, alternatively called beige or brite adipocytes, are incompletely understood. Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker for beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers of beige adipocyte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chronic cold exposure. CD137 knockout mice also showed enhanced cold resistance. These results indicate that CD137 functions as a negative regulator of “browning” in white adipose tissue and call into question the use of this protein as a functional marker for beige adipocytes.
dc.language.isoen
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectBiochemistry & Molecular Biology
dc.subjectadipose tissue metabolism
dc.subjectadipocyte
dc.subjectadipogenesis
dc.subjectadipose tissue
dc.subjectadipokine
dc.subjectbeige adipocyte
dc.subjectbrite adipocyte
dc.subjectthermogenesis
dc.subjectUCP1
dc.subjectBEIGE
dc.subjectADIPOCYTES
dc.subjectDISTINCT
dc.subjectMOUSE
dc.subjectCELL
dc.typeArticle
dc.date.updated2021-04-07T09:18:36Z
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.1074/jbc.AC119.011795
dc.description.sourcetitleJOURNAL OF BIOLOGICAL CHEMISTRY
dc.description.volume295
dc.description.issue7
dc.description.page2034-2042
dc.published.statePublished
dc.grant.idNMRC/CBRG/0107/2016
dc.grant.idNMRC/BnB/018b/2015
dc.grant.id2016-01538
dc.grant.fundingagencyNational Medical Research Council
dc.grant.fundingagencyNational University of Singapore Aspiration Fund Partner
dc.grant.fundingagencySwedish Research Council
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