Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.202005222
Title: HClO-Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image-Guided Bacterial Ablation in Phagocytes
Authors: Wu, Min
Wu, Wenbo 
Duan, Yukun 
Liu, Xingang 
Wang, Meng
Phan, Chi Uyen
Qi, Guobin
Tang, Guping 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission
bacterial infection
nanoprobes
phagocytes
photosensitizers
LIGHT-UP PROBE
HYPOCHLOROUS ACID
PHOTODYNAMIC THERAPY
MYELOPEROXIDASE
ASSEMBLIES
EMISSION
FRET
DNA
Issue Date: 2020
Publisher: WILEY-V C H VERLAG GMBH
Citation: Wu, Min, Wu, Wenbo, Duan, Yukun, Liu, Xingang, Wang, Meng, Phan, Chi Uyen, Qi, Guobin, Tang, Guping, Liu, Bin (2020). HClO-Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image-Guided Bacterial Ablation in Phagocytes. ADVANCED MATERIALS 32 (47). ScholarBank@NUS Repository. https://doi.org/10.1002/adma.202005222
Abstract: Bacteria hiding in host phagocytes are difficult to kill, which can cause phagocyte disorders resulting in local and systemic tissue damage. Effective accumulation of activatable photosensitizers (PSs) in phagocytes to realize selective imaging and on-demand photodynamic ablation of bacteria is of great scientific and practical interests for precise bacteria diagnosis and treatment. Herein, HClO-activatable theranostic nanoprobes, DTF-FFP NPs, for image-guided bacterial ablation in phagocytes are introduced. DTF-FFP NPs are prepared by nanoprecipitation of an HClO-responsive near-infrared molecule FFP and an efficient PS DTF with aggregation-induced emission characteristic using an amphiphilic polymer Pluronic F127 as the encapsulation matrix. As an energy acceptor, FFP can quench both fluorescence and production of reactive oxygen species (ROS) of DTF, thus eliminating the phototoxicity of DTF-FFP NPs in normal cells and tissues. Once delivered to the infection sites, DTF-FFP NPs light up with red fluorescence and efficiently generate ROS owing to the degradation of FFP by the stimulated release of HClO in phagocytes. The selective activation of fluorescence and photosensitization is successfully confirmed by both in vitro and in vivo results, demonstrating the effectiveness and theranostic potential of DTF-FFP NPs in precise bacterial therapy.
Source Title: ADVANCED MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/188665
ISSN: 09359648
15214095
DOI: 10.1002/adma.202005222
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