Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.202012594
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dc.titleAIEgen-Lipid Conjugate for Rapid Labeling of Neutrophils and Monitoring of Their Behavior
dc.contributor.authorLiu, Xingang
dc.contributor.authorWu, Min
dc.contributor.authorWang, Meng
dc.contributor.authorDuan, Yukun
dc.contributor.authorPhan, Chi Uyen
dc.contributor.authorChen, Huan
dc.contributor.authorTang, Guping
dc.contributor.authorLiu, Bin
dc.date.accessioned2021-04-07T03:18:02Z
dc.date.available2021-04-07T03:18:02Z
dc.date.issued2020
dc.identifier.citationLiu, Xingang, Wu, Min, Wang, Meng, Duan, Yukun, Phan, Chi Uyen, Chen, Huan, Tang, Guping, Liu, Bin (2020). AIEgen-Lipid Conjugate for Rapid Labeling of Neutrophils and Monitoring of Their Behavior. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 (6) : 3175-3181. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.202012594
dc.identifier.issn14337851
dc.identifier.issn15213773
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/188601
dc.description.abstractStudies on neutrophil-based nanotherapeutic engineering have shown great potentials in treating infection and inflammation disorders. Conventional neutrophil labeling methods are time-consuming and often result in undesired contamination and activation since neutrophils are terminal-differentiated cells with a half-life span of only 7 h. A simple, fast, and biocompatible strategy to construct engineered neutrophils is highly desirable but remains difficult to achieve. In this study, we present an AIEgen-lipid conjugate, which can efficiently label harvested neutrophils in 30 s with no washing step required. This fast labeling method does not affect the activation and transmigration property of neutrophils, which has been successfully used to monitor neutrophil behaviors such as the chemotaxis process and migrating function towards inflammation sites both in vitro and in vivo, offering a tantalizing prospect for neutrophil-based nanotherapeutics studies.
dc.language.isoen
dc.publisherWILEY-V C H VERLAG GMBH
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectaggregation-induced emission
dc.subjectchemotaxis
dc.subjectfluorescence imaging
dc.subjectinflammation
dc.subjectneutrophil
dc.subjectMEDIATED DELIVERY
dc.subjectMEMBRANE
dc.subjectPHAGOCYTOSIS
dc.subjectINFLAMMATION
dc.subjectRECRUITMENT
dc.subjectTRACKING
dc.subjectCELLS
dc.subjectPROBE
dc.typeArticle
dc.date.updated2021-04-07T00:51:11Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.contributor.departmentDIVISION OF BIOENGINEERING
dc.description.doi10.1002/anie.202012594
dc.description.sourcetitleANGEWANDTE CHEMIE-INTERNATIONAL EDITION
dc.description.volume60
dc.description.issue6
dc.description.page3175-3181
dc.published.statePublished
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