Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.202012594
Title: AIEgen-Lipid Conjugate for Rapid Labeling of Neutrophils and Monitoring of Their Behavior
Authors: Liu, Xingang 
Wu, Min
Wang, Meng
Duan, Yukun 
Phan, Chi Uyen
Chen, Huan 
Tang, Guping 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
aggregation-induced emission
chemotaxis
fluorescence imaging
inflammation
neutrophil
MEDIATED DELIVERY
MEMBRANE
PHAGOCYTOSIS
INFLAMMATION
RECRUITMENT
TRACKING
CELLS
PROBE
Issue Date: 2020
Publisher: WILEY-V C H VERLAG GMBH
Citation: Liu, Xingang, Wu, Min, Wang, Meng, Duan, Yukun, Phan, Chi Uyen, Chen, Huan, Tang, Guping, Liu, Bin (2020). AIEgen-Lipid Conjugate for Rapid Labeling of Neutrophils and Monitoring of Their Behavior. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60 (6) : 3175-3181. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.202012594
Abstract: Studies on neutrophil-based nanotherapeutic engineering have shown great potentials in treating infection and inflammation disorders. Conventional neutrophil labeling methods are time-consuming and often result in undesired contamination and activation since neutrophils are terminal-differentiated cells with a half-life span of only 7 h. A simple, fast, and biocompatible strategy to construct engineered neutrophils is highly desirable but remains difficult to achieve. In this study, we present an AIEgen-lipid conjugate, which can efficiently label harvested neutrophils in 30 s with no washing step required. This fast labeling method does not affect the activation and transmigration property of neutrophils, which has been successfully used to monitor neutrophil behaviors such as the chemotaxis process and migrating function towards inflammation sites both in vitro and in vivo, offering a tantalizing prospect for neutrophil-based nanotherapeutics studies.
Source Title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
URI: https://scholarbank.nus.edu.sg/handle/10635/188601
ISSN: 14337851
15213773
DOI: 10.1002/anie.202012594
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