Please use this identifier to cite or link to this item: https://doi.org/10.3233/JAD-170613
Title: Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease
Authors: Chai, Yuek Ling 
Xing, Huayang
Chong, Joyce R 
Francis, Paul T
Ballard, Clive G
Chen, Christopher P 
Lai, Mitchell KP 
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
mitochondria
oxidative phosphorylation
translocase of the outer membrane
CYTOCHROME-C-OXIDASE
INTERMEMBRANE SPACE
DOWN-SYNDROME
AMYLOID-BETA
PROTEINS
DAMAGE
BRAIN
PATHOGENESIS
MECHANISMS
EXPRESSION
Issue Date: 1-Jan-2018
Publisher: IOS PRESS
Citation: Chai, Yuek Ling, Xing, Huayang, Chong, Joyce R, Francis, Paul T, Ballard, Clive G, Chen, Christopher P, Lai, Mitchell KP (2018-01-01). Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 61 (2) : 793-801. ScholarBank@NUS Repository. https://doi.org/10.3233/JAD-170613
Abstract: The translocase of the outer membrane (TOM) is a vital mitochondrial transport system facilitating the importation of nuclear encoded proteins into the organelle. While mitochondrial dysfunction, including perturbation of oxidative phosphorylation (OXPHOS) complex, is evident in Alzheimer's disease (AD), it remains unclear whether the observed OXPHOS deficits may be associated with TOM alterations. Objectives: To correlate TOM subunits with OXPHOS complex proteins in AD. Methods: Postmortem neocortex (BA40) fromADand age-matched controls were processed to obtain mitochondrial enriched homogenates for the measurement of Tom20, Tom22, Tom40, and Tom70 as well as components of OXPHOS complex I-V by immunoblotting.Results: Tom20 and Tom70 immunoreactivities were significantly reduced in AD, as were components of OXPHOS complex I and III. Both Tom20 and Tom70 positively correlated with complex III and V, while Tom20 also correlated with complex IV. Conclusion: Reductions in certain TOMsubunits and their correlations with specific OXPHOS complex proteins suggest that an impaired mitochondrial transportation system may contribute to previously observed oxidative phosphorylation deficits in AD. Follow-up studies are needed to corroborate the present correlative study.
Source Title: JOURNAL OF ALZHEIMERS DISEASE
URI: https://scholarbank.nus.edu.sg/handle/10635/188522
ISSN: 13872877
18758908
DOI: 10.3233/JAD-170613
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