Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.arr.2015.11.006
DC Field | Value | |
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dc.title | Ageing and the telomere connection: An intimate relationship with inflammation | |
dc.contributor.author | Zhang, Jingwen | |
dc.contributor.author | Rane, Grishma | |
dc.contributor.author | Dai, Xiaoyun | |
dc.contributor.author | Shanmugam, Muthu K | |
dc.contributor.author | Arfuso, Frank | |
dc.contributor.author | Samy, Ramar Perumal | |
dc.contributor.author | Lai, Mitchell Kim Peng | |
dc.contributor.author | Kappei, Dennis | |
dc.contributor.author | Kumar, Alan Prem | |
dc.contributor.author | Sethi, Gautam | |
dc.date.accessioned | 2021-04-06T07:52:11Z | |
dc.date.available | 2021-04-06T07:52:11Z | |
dc.date.issued | 2016-01-01 | |
dc.identifier.citation | Zhang, Jingwen, Rane, Grishma, Dai, Xiaoyun, Shanmugam, Muthu K, Arfuso, Frank, Samy, Ramar Perumal, Lai, Mitchell Kim Peng, Kappei, Dennis, Kumar, Alan Prem, Sethi, Gautam (2016-01-01). Ageing and the telomere connection: An intimate relationship with inflammation. AGEING RESEARCH REVIEWS 25 : 55-69. ScholarBank@NUS Repository. https://doi.org/10.1016/j.arr.2015.11.006 | |
dc.identifier.issn | 15681637 | |
dc.identifier.issn | 18729649 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/188482 | |
dc.description.abstract | Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes, whose length is considered to be a determinant of biological ageing. Normal ageing itself is associated with telomere shortening. Here, critically short telomeres trigger senescence and eventually cell death. This shortening rate may be further increased by inflammation and oxidative stress and thus affect the ageing process. Apart from shortened or dysfunctional telomeres, cells undergoing senescence are also associated with hyperactivity of the transcription factor NF-κB and overexpression of inflammatory cytokines such as TNF-α, IL-6, and IFN-γ in circulating macrophages. Interestingly, telomerase, a reverse transcriptase that elongates telomeres, is involved in modulating NF-κB activity. Furthermore, inflammation and oxidative stress are implicated as pre-disease mechanisms for chronic diseases of ageing such as neurodegenerative diseases, cardiovascular disease, and cancer. To date, inflammation and telomere shortening have mostly been studied individually in terms of ageing and the associated disease phenotype. However, the interdependent nature of the two demands a more synergistic approach in understanding the ageing process itself and for developing new therapeutic approaches. In this review, we aim to summarize the intricate association between the various inflammatory molecules and telomeres that together contribute to the ageing process and related diseases. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cell Biology | |
dc.subject | Geriatrics & Gerontology | |
dc.subject | Telomere | |
dc.subject | Inflammation | |
dc.subject | Ageing | |
dc.subject | NF-KAPPA-B | |
dc.subject | SENSITIVE TRANSCRIPTION FACTORS | |
dc.subject | REPEAT-CONTAINING RNA | |
dc.subject | CD8(+) T-CELLS | |
dc.subject | OXIDATIVE STRESS | |
dc.subject | CELLULAR SENESCENCE | |
dc.subject | UP-REGULATION | |
dc.subject | FUNCTIONAL-CHARACTERIZATION | |
dc.subject | REPLICATIVE SENESCENCE | |
dc.subject | CARDIOVASCULAR-DISEASE | |
dc.type | Review | |
dc.date.updated | 2021-04-03T05:33:06Z | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | PHARMACOLOGY | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.1016/j.arr.2015.11.006 | |
dc.description.sourcetitle | AGEING RESEARCH REVIEWS | |
dc.description.volume | 25 | |
dc.description.page | 55-69 | |
dc.description.place | IRELAND | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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42 Zhang Gautam telomerase ARR 2016.pdf | 1.37 MB | Adobe PDF | CLOSED | None |
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