Please use this identifier to cite or link to this item: https://doi.org/10.3233/JAD-140474
Title: Autoantibodies to GM1 and GQ1b alpha are not Biological Markers of Alzheimer's Disease
Authors: Miura, Yumako 
Miyaji, Kazuki 
Chai, Yuek Ling 
Chen, Christopher LH 
Lai, Mitchell KP 
Yuki, Nobuhiro 
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
anti-ganglioside antibody
biological marker
ganglioside
GUILLAIN-BARRE-SYNDROME
CHOLINERGIC NEURONS
BETA-PROTEIN
GANGLIOSIDE
ANTIBODIES
MODEL
FORM
BRAIN
SERUM
Issue Date: 1-Jan-2014
Publisher: IOS PRESS
Citation: Miura, Yumako, Miyaji, Kazuki, Chai, Yuek Ling, Chen, Christopher LH, Lai, Mitchell KP, Yuki, Nobuhiro (2014-01-01). Autoantibodies to GM1 and GQ1b alpha are not Biological Markers of Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 42 (4) : 1165-1169. ScholarBank@NUS Repository. https://doi.org/10.3233/JAD-140474
Abstract: A few studies have reported the association of autoantibodies to GM1 or GQ1bα with Alzheimer's disease (AD) or vascular dementia. Here we investigated whether patients with AD or vascular dementia had high titers of the anti-ganglioside antibodies. Sera were obtained from patients with AD (n = 22), vascular dementia (n = 14), Guillain-Barré syndrome, and multifocal motor neuropathy as well as normal controls. Enzyme-linked immunosorbent assay showed titers of IgG and IgM anti-GM1, anti-GQ1bα, and anti-GT1aα antibodies did not differ among AD, vascular dementia, and normal controls, and being remarkably lower than those in Guillain-Barré syndrome and multifocal motor neuropathy. The anti-ganglioside antibodies are not biological markers of AD.
Source Title: JOURNAL OF ALZHEIMERS DISEASE
URI: https://scholarbank.nus.edu.sg/handle/10635/188423
ISSN: 13872877
18758908
DOI: 10.3233/JAD-140474
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