Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2005.06.003
Title: Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease
Authors: Garcia-Alloza, Monica
Tsang, Shirley W 
Gil-Bea, Francisco J
Francis, Paul T
Lai, Mitchell K 
Marcos, Beatriz
Chen, Christopher P 
Ramirez, Maria J
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Neurosciences
Neurosciences & Neurology
cognitive deficit
behavioral and psychological syndromes of dementia (BPSD)
GABA
cortex
glutamate
GABA(A) receptors
GABA(B) receptors
benzodiazepine receptors
choline acetyltransferase (ChAT)
AMINO-ACID-CONCENTRATIONS
CHOLINERGIC HYPOTHESIS
MOOD DISORDERS
AGGRESSIVE-BEHAVIOR
GABA(A) RECEPTORS
SUICIDE VICTIMS
BINDING-SITES
HUMAN BRAIN
DEMENTIA
POSTMORTEM
Issue Date: 1-Aug-2006
Publisher: ELSEVIER SCIENCE INC
Citation: Garcia-Alloza, Monica, Tsang, Shirley W, Gil-Bea, Francisco J, Francis, Paul T, Lai, Mitchell K, Marcos, Beatriz, Chen, Christopher P, Ramirez, Maria J (2006-08-01). Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. NEUROBIOLOGY OF AGING 27 (8) : 1110-1117. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2005.06.003
Abstract: Cognitive and neuropsychiatric (BPSD) symptoms seen in Alzheimer's disease (AD) probably result from differential neurotransmitter alterations. The involvement of the glutamatergic and GABAergic system in cognitive and behavioral and psychological symptoms of dementia (BPSD) has been studied in post-mortem frontal and temporal cortex from AD patients who had been prospectively assessed with the Mini-Mental State Examination (MMSE) for cognitive impairment and with the Present Behavioral Examination (PBE) for BPSD. In addition to cholinergic deficits, significant decreases in γ-amino butyric acid (GABA) content, with no changes in glutamate content, were found in frontal and temporal cortex. Both GABA levels and the glutamate/GABA ratio showed significant correlations with depression in AD. In the temporal cortex, higher densities of GABA /benzodiazepine receptors also correlated with more severe depression. It can be suggested that in a situation of cholinergic deficit, such as AD, an imbalance between the excitatory glutamatergic tone and inhibitory GABAergic tone may be responsible for non-cognitive behavioral disturbances. © 2005 Elsevier Inc. All rights reserved.
Source Title: NEUROBIOLOGY OF AGING
URI: https://scholarbank.nus.edu.sg/handle/10635/188371
ISSN: 01974580
15581497
DOI: 10.1016/j.neurobiolaging.2005.06.003
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