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https://doi.org/10.1038/s41598-021-82789-x
Title: | Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes | Authors: | Chen L.-W. Soh S.E. Tint M.-T. Loy S.L. Yap F. Tan K.H. Lee Y.S. Shek L.P.-C. Godfrey K.M. Gluckman P.D. Eriksson J.G. CHONG YAP SENG Chan S.-Y. |
Issue Date: | Mar-2021 | Publisher: | Nature Research | Citation: | Chen L.-W., Soh S.E., Tint M.-T., Loy S.L., Yap F., Tan K.H., Lee Y.S., Shek L.P.-C., Godfrey K.M., Gluckman P.D., Eriksson J.G., CHONG YAP SENG, Chan S.-Y. (2021-03). Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes. Scientific Reports 11 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-021-82789-x | Abstract: | We examined the associations of gestational diabetes mellitus (GDM) and women’s weight status from pre-pregnancy through post-delivery with the risk of developing dysglycaemia [impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes (T2D)] 4–6 years post-delivery. Using Poisson regression with confounder adjustments, we assessed associations of standard categorisations of prospectively ascertained pre-pregnancy overweight and obesity (OWOB), gestational weight gain (GWG) and substantial post-delivery weight retention (PDWR) with post-delivery dysglycaemia (n = 692). Women with GDM had a higher risk of later T2D [relative risk (95% CI) 12.07 (4.55, 32.02)] and dysglycaemia [3.02 (2.19, 4.16)] compared with non-GDM women. Independent of GDM, women with pre-pregnancy OWOB also had a higher risk of post-delivery dysglycaemia. Women with GDM who were OWOB pre-pregnancy and had subsequent PDWR (? 5 kg) had 2.38 times (1.29, 4.41) the risk of post-delivery dysglycaemia compared with pre-pregnancy lean GDM women without PDWR. No consistent associations were observed between GWG and later dysglycaemia risk. In conclusion, women with GDM have a higher risk of T2D 4–6 years after the index pregnancy. Pre-pregnancy OWOB and PDWR exacerbate the risk of post-delivery dysglycaemia. Weight management during preconception and post-delivery represent early windows of opportunity for improving long-term health, especially in those with GDM. © 2021, The Author(s). | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/187261 | ISSN: | 20452322 | DOI: | 10.1038/s41598-021-82789-x |
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