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https://scholarbank.nus.edu.sg/handle/10635/187040
DC Field | Value | |
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dc.title | NEUROCOGNITIVE MECHANISMS OF REGRET AND ITS DYSFUNCTIONS IN DEPRESSION | |
dc.contributor.author | AVIJIT CHOWDHURY | |
dc.date.accessioned | 2021-03-07T18:00:24Z | |
dc.date.available | 2021-03-07T18:00:24Z | |
dc.date.issued | 2020-10-01 | |
dc.identifier.citation | AVIJIT CHOWDHURY (2020-10-01). NEUROCOGNITIVE MECHANISMS OF REGRET AND ITS DYSFUNCTIONS IN DEPRESSION. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/187040 | |
dc.description.abstract | This thesis examines the behavioral and neural correlates of regret in depression. In study 1, a meta-analysis of regret-related fMRI studies (N=19) over a range of tasks showed that the experience of regret led to activations in the rostral anterior cingulate cortex (rACC), the medial orbitofrontal cortex (mOFC), and the striatum. In study 2, I used task-based fMRI to examine alternations in regret-anticipation, experience, and regret-based decision making to show that high levels of depressive-symptoms lead to a blunted experience of regret and a diminished ability to make choices that avoid the potential experience of regret, coupled with diminished activity in the rACC, mOFC, and striatum in anticipation of regret. In study 3, I used a multi-strategy learning game and fMRI to show that the depressed group were less sensitive to history of received-payoff in decisions and showed hypoactivation in the ventral striatum (VS) – suggesting diminished reinforcement learning. | |
dc.language.iso | en | |
dc.subject | regret, fmri, depression, counterfactual, relief, reinforcement learning | |
dc.type | Thesis | |
dc.contributor.department | PSYCHOLOGY | |
dc.contributor.supervisor | RONGJUN YU | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY (FASS) | |
Appears in Collections: | Ph.D Theses (Open) |
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ChowdhuryA.pdf | 10.08 MB | Adobe PDF | OPEN | None | View/Download |
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