Please use this identifier to cite or link to this item: https://doi.org/10.5415/apallergy.2016.6.3.157
Title: Relationship between all fevers or fever after vaccination, and atopy and atopic disorders at 18 and 36 months
Authors: Wong HH
Lee JJ
Shek LP 
Lee BW 
Goh A 
Teoh OH 
Gluckman PD 
Godfrey KM
Saw SM 
Kwek K 
Chong YS 
Van Bever HP 
Keywords: Asthma
Eczema
Fever
Rhinitis
Issue Date: Jul-2016
Citation: Wong HH, Lee JJ, Shek LP, Lee BW, Goh A, Teoh OH, Gluckman PD, Godfrey KM, Saw SM, Kwek K, Chong YS, Van Bever HP (2016-07). Relationship between all fevers or fever after vaccination, and atopy and atopic disorders at 18 and 36 months. Asia Pacific Allergy 6 (3) : 157 - 163. ScholarBank@NUS Repository. https://doi.org/10.5415/apallergy.2016.6.3.157
Abstract: Background: Studies have reported that early febrile episodes and febrile episodes with infections are associated with a decreased risk of developing atopy. Objective: To examine further the association between presence of and number of febrile episodes are with atopy and atopic diseases and if there was a difference between all fevers and fever after vaccination. Methods: We studied 448 infants in a Singapore mother-offspring cohort study (Growing Up in Singapore Towards Healthy Outcomes) which had complete data for the exposures and outcomes of interest. Fever was defined as more than 38.0℃ and was self-reported. The presence of and number of febrile episodes were examined for association with outcome measures, namely parental reports of doctor-diagnosed asthma and eczema, and rhinitis, which was evaluated by doctors involved in the study at 18 and 36 months. These outcomes were considered atopic if there were 1 or more positive skin prick tests. Results: The presence of all fevers from 0-6 months of age was associated with reduced odds of having atopy at 36 months of age (unadjusted odds ratio [OR], 0.628; 95% confidence interval [CI], 0.396-0.995). The presence of fever after vaccination from 0-24 months of age was associated with reduced odds of having atopy at 36 months of age (OR, 0.566; 95% CI, 0.350-0.915). The presence of all fevers from 0-6 months of age was associated with reduced odds of having atopic eczema at 36 months (OR, 0.430; 95% CI, 0.191-0.970). Fever was associated with increased odds of having doctor-diagnosed asthma and rhinitis. Conclusion: There was an inverse relationship between the presence of all fevers from 0-6 months of age and the development of atopy and eczema at 36 months of age. Fever after vaccination might be considered a subclinical infection that did not show the same effect in early life.
Source Title: Asia Pacific Allergy
URI: https://scholarbank.nus.edu.sg/handle/10635/186922
ISSN: 22338276
22338268
DOI: 10.5415/apallergy.2016.6.3.157
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