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|Title:||Surface functionalization of Titanium for Biomedical applications||Authors:||ZHANG FAN||Keywords:||titanium, surface-initiated ATRP, graft polymerization, cell adhesion, osteoblast, antibacterial||Issue Date:||13-Nov-2009||Citation:||ZHANG FAN (2009-11-13). Surface functionalization of Titanium for Biomedical applications. ScholarBank@NUS Repository.||Abstract:||Titanium and its alloys have been widely used in biomedical devices and implants. Additional surface modifications of titanium are usually employed to further enhance biocompatibility and the biological functions, while the intrinsic bulk properties are still retained. In this thesis, surface-initiated atom transfer radical polymerization (ATRP) was explored as an effective approach for surface modification of titanium and tailoring its surface properties. The functional polymer-metal hybrids obtained were found to be stable to hydrolysis. Post-functionalization of the grafted surfaces was carried out via immobilization of bioactive molecules onto the polymer side chains. The compositions of functionalized titanium surfaces were analyzed by X-ray photoelectron spectroscopy (XPS), and assayed for antibacterial activities and cell functions. Silk sericin immobilized surface has the optimal performance among the samples tested. It significantly reduces the adhesion of the two bacteria strains tested, at the same time, promotes osteoblasts adhesion, proliferation, and alkaline phosphatase activity.||URI:||http://scholarbank.nus.edu.sg/handle/10635/18613|
|Appears in Collections:||Ph.D Theses (Open)|
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