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Title: | DEVELOPMENT OF SYNTHETIC BIOPOLYMER/PLANT PROTEIN COMPOSITE SCAFFOLDS VIA ELECTROHYDRODYNAMIC PRINTING FOR POTENTIAL BIOMEDICAL APPLICATIONS | Authors: | JING LINZHI | ORCID iD: | orcid.org/0000-0002-4352-1645 | Keywords: | 3D printing, electrohydrodynamic jet, plant proteins, polycaprolactone, 3D cell culture | Issue Date: | 11-Aug-2020 | Citation: | JING LINZHI (2020-08-11). DEVELOPMENT OF SYNTHETIC BIOPOLYMER/PLANT PROTEIN COMPOSITE SCAFFOLDS VIA ELECTROHYDRODYNAMIC PRINTING FOR POTENTIAL BIOMEDICAL APPLICATIONS. ScholarBank@NUS Repository. | Abstract: | Electrohydrodynamic printing (EHDP) is an emerging 3D printing technique and has attracted growing attention for producing high resolution fibrous scaffolds in 3D cell culture and biomedical applications. However, only a few synthetic biopolymers such as polycaprolactone (PCL) have been used as ink material due to high requirements for ink properties in EHDP, which becomes a major bottleneck. In this thesis, we develop plant proteins/PCL composites inks for EHDP techniques and fabricate PCL/zein and PCL/gliadin composite scaffolds. Compared with PCL scaffold, the zein containing scaffolds exhibit improved tensile strength, biodegradability and biocompatibility in vitro. By leaching gliadin in PCL/gliadin composite, nanoporous scaffolds can be produced and applied to grow tumor cells with improved cell adhesion, proliferation and gene/protein expression. Moreover, we incorporate near-infrared region-II (NIR-II) dyes in PCL inks for establishing a non-invasive tracking method to monitor printed scaffold in vivo. | URI: | https://scholarbank.nus.edu.sg/handle/10635/185991 |
Appears in Collections: | Ph.D Theses (Open) |
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