Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/185873
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dc.titleRelationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study
dc.contributor.authorChong M.F.F.
dc.contributor.authorWong J.X.Y.
dc.contributor.authorColega M.
dc.contributor.authorChen L.-W.
dc.contributor.authorvan Dam R.M.
dc.contributor.authorTan C.S.
dc.contributor.authorLim A.L.
dc.contributor.authorCai S.
dc.contributor.authorBroekman B.F.P.
dc.contributor.authorLee Y.S.
dc.contributor.authorSaw S.M.
dc.contributor.authorKwek K.
dc.contributor.authorGodfrey K.M.
dc.contributor.authorChong Y.S.
dc.contributor.authorGluckman P.
dc.contributor.authorMeaney M.J.
dc.contributor.authorChen H.
dc.contributor.authorAgarwal P.
dc.contributor.authorBiswas A.
dc.contributor.authorBong C.L.
dc.contributor.authorYen Chan J.K.
dc.contributor.authorChan Y.H.
dc.contributor.authorChee C.Y.I.
dc.contributor.authorCheung Y.B.
dc.contributor.authorChia A.
dc.contributor.authorChinnadurai A.
dc.contributor.authorChng C.K.
dc.contributor.authorChong S.C.
dc.contributor.authorChua M.C.
dc.contributor.authorDing C.M.
dc.contributor.authorFinkelstein E.A.
dc.contributor.authorFok D.
dc.contributor.authorFortier M.
dc.contributor.authorGoh A.E.N.
dc.contributor.authorGoh Y.T.D.
dc.contributor.authorGooley J.J.
dc.contributor.authorHan W.M.
dc.contributor.authorHanson M.
dc.contributor.authorHenry C.J.
dc.contributor.authorHolbrook J.D.
dc.contributor.authorHsu C.-Y.
dc.contributor.authorInskip H.
dc.contributor.authorKapur J.
dc.contributor.authorYee-Man Lau I.
dc.contributor.authorLee B.W.
dc.contributor.authorLek N.
dc.contributor.authorLim S.B.
dc.contributor.authorLow Y.-L.
dc.contributor.authorMagiati I.
dc.contributor.authorDaniel L.M.
dc.contributor.authorNgo C.
dc.contributor.authorNaiduvaje K.
dc.contributor.authorPang W.W.
dc.contributor.authorQiu A.
dc.contributor.authorQuah B.L.
dc.contributor.authorRajadurai V.S.
dc.contributor.authorRauff M.
dc.contributor.authorRebello S.A.
dc.contributor.authorRichmond J.L.
dc.contributor.authorRifkin-Graboi A.
dc.contributor.authorPei-Chi Shek L.
dc.contributor.authorSheppard A.
dc.contributor.authorShuter B.
dc.contributor.authorSingh L.
dc.contributor.authorSoh S.-E.
dc.contributor.authorStunkel W.
dc.contributor.authorSu L.L.
dc.contributor.authorTan K.H.
dc.contributor.authorTeoh O.H.
dc.contributor.authorTint M.T.
dc.contributor.authorvan Bever H.P.S.
dc.contributor.authorYun Wong I.B.
dc.contributor.authorWong P.C.
dc.contributor.authorYap F.
dc.contributor.authorHeong Yeo G.S.
dc.date.accessioned2021-01-27T07:42:53Z
dc.date.available2021-01-27T07:42:53Z
dc.date.issued2014
dc.identifier.citationChong M.F.F., Wong J.X.Y., Colega M., Chen L.-W., van Dam R.M., Tan C.S., Lim A.L., Cai S., Broekman B.F.P., Lee Y.S., Saw S.M., Kwek K., Godfrey K.M., Chong Y.S., Gluckman P., Meaney M.J., Chen H., Agarwal P., Biswas A., Bong C.L., Yen Chan J.K., Chan Y.H., Chee C.Y.I., Cheung Y.B., Chia A., Chinnadurai A., Chng C.K., Chong S.C., Chua M.C., Ding C.M., Finkelstein E.A., Fok D., Fortier M., Goh A.E.N., Goh Y.T.D., Gooley J.J., Han W.M., Hanson M., Henry C.J., Holbrook J.D., Hsu C.-Y., Inskip H., Kapur J., Yee-Man Lau I., Lee B.W., Lek N., Lim S.B., Low Y.-L., Magiati I., Daniel L.M., Ngo C., Naiduvaje K., Pang W.W., Qiu A., Quah B.L., Rajadurai V.S., Rauff M., Rebello S.A., Richmond J.L., Rifkin-Graboi A., Pei-Chi Shek L., Sheppard A., Shuter B., Singh L., Soh S.-E., Stunkel W., Su L.L., Tan K.H., Teoh O.H., Tint M.T., van Bever H.P.S., Yun Wong I.B., Wong P.C., Yap F., Heong Yeo G.S. (2014). Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. Journal of Psychiatric Research 55 (1) : 110 - 116. ScholarBank@NUS Repository.
dc.identifier.issn00223956
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/185873
dc.description.abstractStudies in the general population have proposed links between nutrition and depression, but less is known about the perinatal period. Depletion of nutrient reserves throughout pregnancy and delayed postpartum repletion could increase the risk of perinatal depression. We examined the relationships of plasma folate and vitamin B12 concentrations during pregnancy with perinatal depression. At 26th-28th weeks of gestation, plasma folate and vitamin B12 were measured in women from the GUSTO mother-offspring cohort study in Singapore. Depressive symptoms were measured with the Edinburgh Postnatal Depression Scale (EPDS) during the same period and at 3-month postpartum. EPDS scores of ≥15 during pregnancy or ≥13 at postpartum were indicative of probable depression. Of 709 women, 7.2% (n=51) were identified with probable antenatal depression and 10.4% (n=74) with probable postnatal depression. Plasma folate concentrations were significantly lower in those with probable antenatal depression than those without (mean±SD; 27.3±13.8 vs 40.4±36.5nmol/L; p=0.011). No difference in folate concentrations was observed in those with and without probable postnatal depression. In adjusted regression models, the likelihood of probable antenatal depression decreases by 0.69 for every unit variation (increase) in folate (OR=0.69 per SD increase in folate; 95% CI: 0.52, 0.94). Plasma vitamin B12 concentrations were not associated with perinatal depression. Lower plasma folate status during pregnancy was associated with antenatal depression, but not with postnatal depression. Replication in other studies is needed to determine the direction of causality between low folate and antenatal depression. Clinical trial registry: NCT01174875. © 2014 Elsevier Ltd.
dc.language.isoen
dc.publisherElsevier Ltd
dc.sourceScopus
dc.subjectAntenatal depression
dc.subjectEdinburgh Postnatal Depression Scale
dc.subjectFolate
dc.subjectPostnatal depression
dc.subjectPregnancy diet
dc.subjectVitamin B12
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPAEDIATRICS
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.contributor.departmentPSYCHOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.sourcetitleJournal of Psychiatric Research
dc.description.volume55
dc.description.issue1
dc.description.page110 - 116
dc.description.codenJPYRA
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.published.statePublished
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.fundingagencyNational Medical Research Council
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