Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/185740
DC Field | Value | |
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dc.title | PROTEIN ALLOSTERY: FROM BASIC MECHANISMS TO COMPUTATIONAL MODELLING | |
dc.contributor.author | TEE WEI VEN | |
dc.date.accessioned | 2021-01-25T18:00:30Z | |
dc.date.available | 2021-01-25T18:00:30Z | |
dc.date.issued | 2020-07-01 | |
dc.identifier.citation | TEE WEI VEN (2020-07-01). PROTEIN ALLOSTERY: FROM BASIC MECHANISMS TO COMPUTATIONAL MODELLING. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/185740 | |
dc.description.abstract | Allostery is a phenomenon in which a protein’s functional activity is regulated by a perturbation at a distant site. Allosteric control of proteins by ligand binding, mutations, and structural disorder is explored here using a structure-based statistical mechanical model of allostery. The following findings will be presented: first, reversing allosteric communication identifies known allosteric sites and suggests latent allosteric sites; second, Allosteric Signaling Maps (ASMs), derived by exhaustive mutational scanning over all amino acids, allow to examine the allosteric effects of distal mutations quantitatively; third, allosteric regulation driven by structural disorder and order, and their transitions, will be explored in several proteins. The computationally efficient method is implemented as an online web-server called AlloSigMA2 to quantify the allosteric signaling originated from user-defined site(s) and/or mutation(s). Lastly, an online database AlloMAPS which contains the comprehensive description on allosteric signaling in more than 2,000 proteins and protein domains will be presented. | |
dc.language.iso | en | |
dc.subject | allostery, protein dynamics, computational modelling, mutation, intrinsic disorder | |
dc.type | Thesis | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.supervisor | Igor Berezovsky | |
dc.contributor.supervisor | Ganesh Srinivasan Anand | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY (FOS) | |
Appears in Collections: | Ph.D Theses (Open) |
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TeeWV.pdf | 7.39 MB | Adobe PDF | OPEN | None | View/Download |
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