Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-20171-7
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dc.titleIntratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
dc.contributor.authorNguyen, Phuong HD
dc.contributor.authorMa, Siming
dc.contributor.authorPhua, Cheryl ZJ
dc.contributor.authorKaya, Neslihan A
dc.contributor.authorLai, Hannah LH
dc.contributor.authorLim, Chun Jye
dc.contributor.authorLim, Jia Qi
dc.contributor.authorWasser, Martin
dc.contributor.authorLai, Liyun
dc.contributor.authorTam, Wai Leong
dc.contributor.authorLim, Tony KH
dc.contributor.authorWan, Wei Keat
dc.contributor.authorLoh, Tracy
dc.contributor.authorLeow, Wei Qiang
dc.contributor.authorPang, Yin Huei
dc.contributor.authorChan, Chung Yip
dc.contributor.authorLee, Ser Yee
dc.contributor.authorCheow, Peng Chung
dc.contributor.authorToh, Han Chong
dc.contributor.authorGinhoux, Florent
dc.contributor.authorIyer, Shridhar
dc.contributor.authorKow, Alfred WC
dc.contributor.authorYoung Dan, Yock
dc.contributor.authorChung, Alexander
dc.contributor.authorGoh, Brian KP
dc.contributor.authorAlbani, Salvatore
dc.contributor.authorChow, Pierce KH
dc.contributor.authorZhai, Weiwei
dc.contributor.authorChew, Valerie
dc.date.accessioned2021-01-14T04:52:11Z
dc.date.available2021-01-14T04:52:11Z
dc.date.issued2021-12
dc.identifier.citationNguyen, Phuong HD, Ma, Siming, Phua, Cheryl ZJ, Kaya, Neslihan A, Lai, Hannah LH, Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony KH, Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred WC, Young Dan, Yock, Chung, Alexander, Goh, Brian KP, Albani, Salvatore, Chow, Pierce KH, Zhai, Weiwei, Chew, Valerie (2021-12). Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma. Nature Communications 12 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-20171-7
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/185502
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial and phenotypic immune-ITH from multiple tumour sectors and decipher its relationship with tumour evolution and disease progression in hepatocellular carcinomas (HCC). Immune-ITH is associated with tumour transcriptomic-ITH, mutational burden and distinct immune microenvironments. Tumours with low immune-ITH experience higher immunoselective pressure and escape via loss of heterozygosity in human leukocyte antigens and immunoediting. Instead, the tumours with high immune-ITH evolve to a more immunosuppressive/exhausted microenvironment. This gradient of immune pressure along with immune-ITH represents a hallmark of tumour evolution, which is closely linked to the transcriptome-immune networks contributing to disease progression and immune inactivation. Remarkably, high immune-ITH and its transcriptomic signature are predictive for worse clinical outcome in HCC patients. This in-depth investigation of ITH provides evidence on tumour-immune co-evolution along HCC progression.</jats:p>
dc.publisherSpringer Science and Business Media LLC
dc.sourceElements
dc.typeArticle
dc.date.updated2021-01-14T03:41:18Z
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.contributor.departmentDEPT OF SURGERY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentRISK MANAGEMENT INSTITUTE
dc.description.doi10.1038/s41467-020-20171-7
dc.description.sourcetitleNature Communications
dc.description.volume12
dc.description.issue1
dc.published.statePublished
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