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Title: | DEFINING THE FUNCTIONAL BASIS FOR HEPATITIS B VIRUS (HBV) NEUTRALIZATION BY A HUMAN ANTIBODY | Authors: | SAKET JHAJHARIA | Keywords: | Hepatitis B Virus, HBV, Antibody, Neutralizing, B cells, Memory | Issue Date: | 1-Dec-2020 | Citation: | SAKET JHAJHARIA (2020-12-01). DEFINING THE FUNCTIONAL BASIS FOR HEPATITIS B VIRUS (HBV) NEUTRALIZATION BY A HUMAN ANTIBODY. ScholarBank@NUS Repository. | Abstract: | HBV poses a serious global health problem with treatment options limited to nucleoside analogs, IFN-α, or HBIG. HBIG is derived from pooled plasma of HBV-vaccinated donors and suffers from low specific activity and batch variation. In theory, treatment with HBV mAbs should allow for higher specificity and easier manufacture. However, treatment with HBV-specific mAbs is complicated by our insufficient understanding of the antibody responses generated in an HBV infection and disease resolution. In this study, we present the first fully human neutralizing antibody isolated from an acute recovered patient by screening against live virus. Ab11 showed 100-fold better neutralizing potential compared to HBIG, bound to the four major HBV genotypes (A, B, C, D) and specific to a conformational epitope found on HBV S-antigen. In-vivo, Ab11 significantly reduced HBV DNA levels and circulating HBsAg compared to HBIG, indicating potential use as a prophylactic or therapeutic for medical intervention in HBV. | URI: | https://scholarbank.nus.edu.sg/handle/10635/184540 |
Appears in Collections: | Ph.D Theses (Open) |
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