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Title: | THE ROLE OF T-BET IN LUNG INFECTION | Authors: | ER JUN ZHI | ORCID iD: | orcid.org/0000-0003-2472-1008 | Keywords: | T-bet, Eomes, Influenza, Bacteria, Superinfection, Lung | Issue Date: | 25-Jan-2019 | Citation: | ER JUN ZHI (2019-01-25). THE ROLE OF T-BET IN LUNG INFECTION. ScholarBank@NUS Repository. | Abstract: | The T-box transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. In this thesis, a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral clearance or recovery compared to wild-type hosts. Instead, elevated IL-17 production by CD8+, CD4+ and γδ T cells, as well as increased infiltration of neutrophils in the lungs of influenza virus infected T-bet-/- mice contributed to survival advantage against secondary Streptococcus pneumoniae infection. During infection, inverse expression of T-bet and another homologous T-box factor, Eomesodermin (Eomes), in natural killer cells was observed. To further understand immunomodulatory mechanisms of T-bet, we further explored the regulatory effects of T-bet on Eomes. Together, our results provide the possibility of targeting T-bet activity for positive outcomes from lethal bacterial superinfection without affecting influenza viral clearance. | URI: | https://scholarbank.nus.edu.sg/handle/10635/184310 |
Appears in Collections: | Ph.D Theses (Open) |
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