Please use this identifier to cite or link to this item: https://doi.org/10.4103/0377-4929.68301
DC FieldValue
dc.titlep16INK4A and MIB-1: An immunohistochemical expression in preneoplasia and neoplasia of the cervix
dc.contributor.authorSrivastava, Supriya
dc.date.accessioned2020-11-27T08:44:06Z
dc.date.available2020-11-27T08:44:06Z
dc.date.issued2010-07-01
dc.identifier.citationSrivastava, Supriya (2010-07-01). p16INK4A and MIB-1: An immunohistochemical expression in preneoplasia and neoplasia of the cervix. INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY 53 (3) : 518-524. ScholarBank@NUS Repository. https://doi.org/10.4103/0377-4929.68301
dc.identifier.issn03774929
dc.identifier.issn09745130
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/184190
dc.description.abstractAIM: To evaluate the potential of p16INK4A and MIB-1 and to compare the expression and interrelationship of these markers in cervical preneoplasias and neoplasias. MATERIALS AND METHODS: Immunohistochemical analysis of p16 and MIB-1 was performed in n = 63 tissue sections and by matching the corresponding Papanicolaou smears. Staining intensity for p16 was determined using the 0-3 grading system. For MIB-1, labelling indices (LI) were calculated and grading was performed using the I-III scoring system. RESULTS: No positive staining of p16 was observed in the normal cervical epithelium. With increasing severity of cervical intraepithelial neoplasias (CIN), the p16 expression increased progressively. Significant up-regulation of p16 was observed in carcinoma cervix. MIB-1 LI was observed to increase with increasing grades of CIN, and significant overexpression of MIB-1 was observed in carcinoma cervix. Correlation between grades of p16 and that of MIB-1 among cervical neoplasias showed an increasing p16 expression with consistently increasing MIB-1 LI in the groups of increasing severity. CONCLUSION: This pattern of overexpression of p16 and MIB-1 demonstrate their use as a diagnostic marker for cervical neoplastic lesion. Therefore, p16 and MIB-1 markers in tissue sections can be used as an adjunct to definitively diagnose preneoplastic and neoplastic lesions in the cervix.
dc.language.isoen
dc.publisherMEDKNOW PUBLICATIONS
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPathology
dc.subjectp16INK4A
dc.subjectMIB-1
dc.subjectimmunohistochemistry
dc.subjectcervix carcinoma
dc.subjectPapanicolaou smear
dc.subjectEPITHELIAL-CELLS
dc.subjectP16(INK4A)
dc.subjectMARKER
dc.subjectBIOMARKERS
dc.subjectPROTEIN
dc.subjectCANCER
dc.subjectSMEARS
dc.subjectKI-67
dc.subjectRISK
dc.subjectP16
dc.typeArticle
dc.date.updated2020-11-27T06:33:06Z
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.4103/0377-4929.68301
dc.description.sourcetitleINDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
dc.description.volume53
dc.description.issue3
dc.description.page518-524
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Indian J Pathol Microbiol_2010_Jun.docx13.43 kBMicrosoft Word XML

OPEN

PublishedView/Download

SCOPUSTM   
Citations

10
checked on May 12, 2021

Page view(s)

75
checked on May 13, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.