Please use this identifier to cite or link to this item: https://doi.org/10.4103/0377-4929.68301
Title: p16INK4A and MIB-1: An immunohistochemical expression in preneoplasia and neoplasia of the cervix
Authors: Srivastava, Supriya 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pathology
p16INK4A
MIB-1
immunohistochemistry
cervix carcinoma
Papanicolaou smear
EPITHELIAL-CELLS
P16(INK4A)
MARKER
BIOMARKERS
PROTEIN
CANCER
SMEARS
KI-67
RISK
P16
Issue Date: 1-Jul-2010
Publisher: MEDKNOW PUBLICATIONS
Citation: Srivastava, Supriya (2010-07-01). p16INK4A and MIB-1: An immunohistochemical expression in preneoplasia and neoplasia of the cervix. INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY 53 (3) : 518-524. ScholarBank@NUS Repository. https://doi.org/10.4103/0377-4929.68301
Abstract: AIM: To evaluate the potential of p16INK4A and MIB-1 and to compare the expression and interrelationship of these markers in cervical preneoplasias and neoplasias. MATERIALS AND METHODS: Immunohistochemical analysis of p16 and MIB-1 was performed in n = 63 tissue sections and by matching the corresponding Papanicolaou smears. Staining intensity for p16 was determined using the 0-3 grading system. For MIB-1, labelling indices (LI) were calculated and grading was performed using the I-III scoring system. RESULTS: No positive staining of p16 was observed in the normal cervical epithelium. With increasing severity of cervical intraepithelial neoplasias (CIN), the p16 expression increased progressively. Significant up-regulation of p16 was observed in carcinoma cervix. MIB-1 LI was observed to increase with increasing grades of CIN, and significant overexpression of MIB-1 was observed in carcinoma cervix. Correlation between grades of p16 and that of MIB-1 among cervical neoplasias showed an increasing p16 expression with consistently increasing MIB-1 LI in the groups of increasing severity. CONCLUSION: This pattern of overexpression of p16 and MIB-1 demonstrate their use as a diagnostic marker for cervical neoplastic lesion. Therefore, p16 and MIB-1 markers in tissue sections can be used as an adjunct to definitively diagnose preneoplastic and neoplastic lesions in the cervix.
Source Title: INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/184190
ISSN: 03774929
09745130
DOI: 10.4103/0377-4929.68301
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