Please use this identifier to cite or link to this item: https://doi.org/10.1182/blood-2005-07-2965
Title: Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors
Authors: Piqueras, B
Connolly, J 
Freitas, H
Palucka, A.K
Banchereau, J
Keywords: chemokine
CXCL9 chemokine
gamma interferon inducible protein 10
interleukin 8
macrophage inflammatory protein 3beta
RANTES
article
B lymphocyte
bone marrow cell
cytotoxic T lymphocyte
dendritic cell
effector cell
human
human cell
human experiment
immune response
Influenza virus
innate immunity
lymphoid organ
memory T lymphocyte
natural killer cell
neutrophil
normal human
plasma cell
priority journal
T lymphocyte
virus infection
Antigen-Presenting Cells
CD4-Positive T-Lymphocytes
Cell Movement
Cytokines
Dendritic Cells
Epithelial Cells
Humans
Immunologic Memory
Kinetics
Oligonucleotide Array Sequence Analysis
Orthomyxoviridae
Transcription, Genetic
Issue Date: 2006
Publisher: American Society of Hematology
Citation: Piqueras, B, Connolly, J, Freitas, H, Palucka, A.K, Banchereau, J (2006). Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Blood 107 (7) : 2613-2618. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2005-07-2965
Rights: Attribution 4.0 International
Abstract: Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs to be coordinated to ensure protection. Here we show that influenza virus triggers, in human blood dendritic-cell (DC) subsets (ie, plasmacytoid and myeloid DCs), a coordinated chemokine (CK) secretion program with 3 successive waves. The first one, occurring at early time points (2 to 4 hours), includes CKs potentially attracting effector cells such as neutrophils, cytotoxic T cells, and natural killer (NK) cells (CXCL16, CXCL1, CXCL2, and CXCL3). The second one occurs within 8 to 12 hours and includes CKs attracting effector memory T cells (CXCL8, CCL3, CCL4, CCL5, CXCL9, CXCL10, and CXCL11). The third wave, which occurs after 24 to 48 hours, when DCs have reached the lymphoid organs, includes CCL19, CCL22, and CXCL13, which attract naive T and B lymphocytes. Thus, human blood DC subsets carry a common program of CK production, which allows for a coordinated attraction of the different immune effectors in response to viral infection. © 2006 by The American Society of Hematology.
Source Title: Blood
URI: https://scholarbank.nus.edu.sg/handle/10635/183930
ISSN: 0006-4971
DOI: 10.1182/blood-2005-07-2965
Rights: Attribution 4.0 International
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