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https://doi.org/10.1182/blood-2005-07-2965
Title: | Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors | Authors: | Piqueras, B Connolly, J Freitas, H Palucka, A.K Banchereau, J |
Keywords: | chemokine CXCL9 chemokine gamma interferon inducible protein 10 interleukin 8 macrophage inflammatory protein 3beta RANTES article B lymphocyte bone marrow cell cytotoxic T lymphocyte dendritic cell effector cell human human cell human experiment immune response Influenza virus innate immunity lymphoid organ memory T lymphocyte natural killer cell neutrophil normal human plasma cell priority journal T lymphocyte virus infection Antigen-Presenting Cells CD4-Positive T-Lymphocytes Cell Movement Cytokines Dendritic Cells Epithelial Cells Humans Immunologic Memory Kinetics Oligonucleotide Array Sequence Analysis Orthomyxoviridae Transcription, Genetic |
Issue Date: | 2006 | Publisher: | American Society of Hematology | Citation: | Piqueras, B, Connolly, J, Freitas, H, Palucka, A.K, Banchereau, J (2006). Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Blood 107 (7) : 2613-2618. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2005-07-2965 | Rights: | Attribution 4.0 International | Abstract: | Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs to be coordinated to ensure protection. Here we show that influenza virus triggers, in human blood dendritic-cell (DC) subsets (ie, plasmacytoid and myeloid DCs), a coordinated chemokine (CK) secretion program with 3 successive waves. The first one, occurring at early time points (2 to 4 hours), includes CKs potentially attracting effector cells such as neutrophils, cytotoxic T cells, and natural killer (NK) cells (CXCL16, CXCL1, CXCL2, and CXCL3). The second one occurs within 8 to 12 hours and includes CKs attracting effector memory T cells (CXCL8, CCL3, CCL4, CCL5, CXCL9, CXCL10, and CXCL11). The third wave, which occurs after 24 to 48 hours, when DCs have reached the lymphoid organs, includes CCL19, CCL22, and CXCL13, which attract naive T and B lymphocytes. Thus, human blood DC subsets carry a common program of CK production, which allows for a coordinated attraction of the different immune effectors in response to viral infection. © 2006 by The American Society of Hematology. | Source Title: | Blood | URI: | https://scholarbank.nus.edu.sg/handle/10635/183930 | ISSN: | 0006-4971 | DOI: | 10.1182/blood-2005-07-2965 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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