Please use this identifier to cite or link to this item:
https://doi.org/10.3174/ajnr.A1413
DC Field | Value | |
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dc.title | Graves ophthalmopathy: The bony orbit in optic neuropathy, its apical angular capacity, and impact on prediction of risk | |
dc.contributor.author | Chan, L.-L | |
dc.contributor.author | Tan, H.-E | |
dc.contributor.author | Fook-Chong, S | |
dc.contributor.author | Teo, T.-H | |
dc.contributor.author | Lim, L.-H | |
dc.contributor.author | Seah, L.-L | |
dc.date.accessioned | 2020-11-23T09:01:45Z | |
dc.date.available | 2020-11-23T09:01:45Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Chan, L.-L, Tan, H.-E, Fook-Chong, S, Teo, T.-H, Lim, L.-H, Seah, L.-L (2009). Graves ophthalmopathy: The bony orbit in optic neuropathy, its apical angular capacity, and impact on prediction of risk. American Journal of Neuroradiology 30 (3) : 597-602. ScholarBank@NUS Repository. https://doi.org/10.3174/ajnr.A1413 | |
dc.identifier.issn | 0195-6108 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/183920 | |
dc.description.abstract | Optic neuropathy (ON), a serious complication of Graves ophthalmopathy, is often subclinical and masked by symptoms of orbitopathy. We examined herein bony and soft-tissue CT features associated with ON, including an angular assessment of orbital apex capacity, and their usefulness in the risk prediction of ON. MATERIALS AND METHODS: The CT scans of 41 patients with Graves ophthalmopathy (17 men, 24 women; mean age, 49.1 years) clinically diagnosed with (19 patients, 32 orbits) or without ON were evaluated by 2 independent raters. Quantitative linear and angular measurements of the orbital structures and bony walls and categoric scores of apical crowding and intracranial fat prolapse were assessed on a clinical workstation. Inter- and intrarater variability of these features was determined. The CT features of the 2 patient groups were compared, and multivariate logistic regression analysis was performed to evaluate the predictive features of ON. RESULTS: Bony orbital angles (P < .005), length of the lateral orbital wall (P< .05), muscular diameters (P < .0005), muscular bulk of the medial rectus muscle relative to the bony orbit (P < .05), and apical crowding (P < .0005) were associated with clinical ON. Stepwise multivariate logistic regression analysis revealed the muscle diameter index and medial and lateral wall angles to be independent predictors. Combining these in a single multivariate equation yielded sensitivity, specificity, and positive and negative predictive values of 73%, 90%, 82%, and 85%, respectively. CONCLUSIONS: Orbital wall angles, especially the medial wall, and muscular enlargement are independent risk predictors. | |
dc.publisher | American Society of Neuroradiology | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | adult | |
dc.subject | article | |
dc.subject | clinical article | |
dc.subject | computer assisted tomography | |
dc.subject | endocrine ophthalmopathy | |
dc.subject | female | |
dc.subject | human | |
dc.subject | male | |
dc.subject | optic nerve disease | |
dc.subject | orbit | |
dc.subject | prediction | |
dc.subject | risk assessment | |
dc.subject | sensitivity and specificity | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Female | |
dc.subject | Graves Ophthalmopathy | |
dc.subject | Humans | |
dc.subject | Logistic Models | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Multivariate Analysis | |
dc.subject | Oculomotor Muscles | |
dc.subject | Optic Nerve | |
dc.subject | Optic Nerve Diseases | |
dc.subject | Orbit | |
dc.subject | Predictive Value of Tests | |
dc.subject | Risk Factors | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Severity of Illness Index | |
dc.subject | Tomography, X-Ray Computed | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.description.doi | 10.3174/ajnr.A1413 | |
dc.description.sourcetitle | American Journal of Neuroradiology | |
dc.description.volume | 30 | |
dc.description.issue | 3 | |
dc.description.page | 597-602 | |
dc.published.state | published | |
Appears in Collections: | Staff Publications Elements |
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