Please use this identifier to cite or link to this item:
https://doi.org/10.1182/blood-2010-06-289207
DC Field | Value | |
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dc.title | Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation | |
dc.contributor.author | Kharazi, S | |
dc.contributor.author | Mead, A.J | |
dc.contributor.author | Mansour, A | |
dc.contributor.author | Hultquist, A | |
dc.contributor.author | Böiers, C | |
dc.contributor.author | Luc, S | |
dc.contributor.author | Buza-Vidas, N | |
dc.contributor.author | Ma, Z | |
dc.contributor.author | Ferry, H | |
dc.contributor.author | Atkinson, D | |
dc.contributor.author | Reckzeh, K | |
dc.contributor.author | Masson, K | |
dc.contributor.author | Cammenga, J | |
dc.contributor.author | Rönnstrand, L | |
dc.contributor.author | Arai, F | |
dc.contributor.author | Suda, T | |
dc.contributor.author | Nerlov, C | |
dc.contributor.author | Sitnicka, E | |
dc.contributor.author | Jacobsen, S.E.W | |
dc.date.accessioned | 2020-11-23T09:00:14Z | |
dc.date.available | 2020-11-23T09:00:14Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Kharazi, S, Mead, A.J, Mansour, A, Hultquist, A, Böiers, C, Luc, S, Buza-Vidas, N, Ma, Z, Ferry, H, Atkinson, D, Reckzeh, K, Masson, K, Cammenga, J, Rönnstrand, L, Arai, F, Suda, T, Nerlov, C, Sitnicka, E, Jacobsen, S.E.W (2011). Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation. Blood 118 (13) : 3613-3621. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2010-06-289207 | |
dc.identifier.issn | 0006-4971 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/183912 | |
dc.description.abstract | Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis and are frequently detected at relapse. Using a mouse knockin model of Flt3 - internal tandem duplication (Flt3-ITD) - induced myeloproliferation, we herein demonstrate that the enhanced myeloid phenotype and expansion of granulocyte-monocyte and primitive Lin -Sca1 +c-Kit + progenitors in Flt3-ITD homozygous mice can in part be mediated through the loss of the second wild-type allele. Further, whereas autocrine FLT3 ligand production has been implicated in FLT3-ITD myeloid malignancies and resistance to FLT3 inhibitors, we demonstrate here that the mouse Flt3 ITD/ITD myeloid phenotype is FLT3 ligand-independent. © 2011 by The American Society of Hematology. | |
dc.publisher | American Society of Hematology | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | ataxin 1 | |
dc.subject | Flt3 ligand | |
dc.subject | stem cell factor | |
dc.subject | allele | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | article | |
dc.subject | cell expansion | |
dc.subject | controlled study | |
dc.subject | cytokine production | |
dc.subject | gene dosage | |
dc.subject | gene duplication | |
dc.subject | gene loss | |
dc.subject | gene targeting | |
dc.subject | granulocyte | |
dc.subject | internal tandem duplication | |
dc.subject | monocyte | |
dc.subject | mouse | |
dc.subject | myeloproliferative disorder | |
dc.subject | nonhuman | |
dc.subject | phenotype | |
dc.subject | priority journal | |
dc.subject | wild type | |
dc.subject | Alleles | |
dc.subject | Animals | |
dc.subject | Bone Marrow Cells | |
dc.subject | Cell Proliferation | |
dc.subject | Cells, Cultured | |
dc.subject | fms-Like Tyrosine Kinase 3 | |
dc.subject | Gene Dosage | |
dc.subject | Gene Duplication | |
dc.subject | Gene Knock-In Techniques | |
dc.subject | Loss of Heterozygosity | |
dc.subject | Male | |
dc.subject | Membrane Proteins | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Transgenic | |
dc.subject | Myeloproliferative Disorders | |
dc.subject | Phenotype | |
dc.subject | Tandem Repeat Sequences | |
dc.type | Article | |
dc.contributor.department | DEPT OF MEDICINE | |
dc.description.doi | 10.1182/blood-2010-06-289207 | |
dc.description.sourcetitle | Blood | |
dc.description.volume | 118 | |
dc.description.issue | 13 | |
dc.description.page | 3613-3621 | |
dc.published.state | published | |
Appears in Collections: | Staff Publications Elements |
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