Please use this identifier to cite or link to this item: https://doi.org/10.4269/ajtmh.14-0628
Title: Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore
Authors: Yung, C.-F
Lee, K.-S
Thein, T.-L
Tan, L.-K
Gan, V.C
Wong, J.G.X
Lye, D.C 
Ng, L.-C
Leo, Y.-S 
Keywords: envelope protein
nonstructural protein 1
virus protein
virus RNA
virus antibody
abdominal pain
adult
aged
arthralgia
Article
clinical feature
dengue
Dengue virus
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
disease severity
drowsiness
female
fever
genotype
hematocrit
hematological parameters
human
infection risk
leukocyte count
major clinical study
male
mucosal bleeding
outcome assessment
prospective study
protein blood level
real time polymerase chain reaction
reverse transcription polymerase chain reaction
serotype
Singapore
species difference
systolic blood pressure
thrombocyte count
world health organization
adolescent
blood
classification
cohort analysis
dengue
Dengue virus
genetics
immunology
isolation and purification
middle aged
risk
serotype
serotyping
Severe Dengue
severity of illness index
very elderly
virology
young adult
Dengue virus
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral
Cohort Studies
Dengue
Dengue Virus
Female
Genotype
Humans
Male
Middle Aged
Prospective Studies
Risk
RNA, Viral
Serogroup
Serotyping
Severe Dengue
Severity of Illness Index
Singapore
Species Specificity
Young Adult
Issue Date: 2015
Publisher: American Society of Tropical Medicine and Hygiene
Citation: Yung, C.-F, Lee, K.-S, Thein, T.-L, Tan, L.-K, Gan, V.C, Wong, J.G.X, Lye, D.C, Ng, L.-C, Leo, Y.-S (2015). Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. American Journal of Tropical Medicine and Hygiene 92 (5) : 999-1005. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.14-0628
Rights: Attribution 4.0 International
Abstract: Studies on serotype-specific features of dengue and disease severity on adults are limited. We prospectively recruited adult febrile patients without alternate diagnosis to dengue from April 2005 to December 2011. Outcomes were defined using both the World Health Organization (WHO) 1997 and 2009 criteria; Dengue hemorrhagic fever (DHF) and severe dengue (SD). Infecting serotype was identified in 469 dengue-confirmed patients comprising 22.0% dengue virus serotype 1 (DENV-1), 57.1% DENV-2, 17.1% DENV-3, and 3.8% DENV-4. Cases infected with DENV-1 were more likely to present with red eyes whereas presence of joint pain and lower platelet count was associated with DENV-2 cases. After adjusting for potential confounders, DENV-1 was associated with both DHF (adjusted Relative Risk [aRR] = 1.74) and SD (aRR = 2.1) whereas DENV-2 had a lower risk of DHF (aRR = 0.5). DENV-1 genotype 1 and DENV-2 cosmopolitan were the predominant genotypes identified. Infecting dengue serotype and possibly genotype may play an important role in disease severity among adult dengue patients in Singapore. Copyright © 2015 by The American Society of Tropical Medicine and Hygiene.
Source Title: American Journal of Tropical Medicine and Hygiene
URI: https://scholarbank.nus.edu.sg/handle/10635/183890
ISSN: 0002-9637
DOI: 10.4269/ajtmh.14-0628
Rights: Attribution 4.0 International
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