Please use this identifier to cite or link to this item: https://doi.org/10.4269/ajtmh.14-0628
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dc.titleDengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore
dc.contributor.authorYung, C.-F
dc.contributor.authorLee, K.-S
dc.contributor.authorThein, T.-L
dc.contributor.authorTan, L.-K
dc.contributor.authorGan, V.C
dc.contributor.authorWong, J.G.X
dc.contributor.authorLye, D.C
dc.contributor.authorNg, L.-C
dc.contributor.authorLeo, Y.-S
dc.date.accessioned2020-11-23T08:56:23Z
dc.date.available2020-11-23T08:56:23Z
dc.date.issued2015
dc.identifier.citationYung, C.-F, Lee, K.-S, Thein, T.-L, Tan, L.-K, Gan, V.C, Wong, J.G.X, Lye, D.C, Ng, L.-C, Leo, Y.-S (2015). Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. American Journal of Tropical Medicine and Hygiene 92 (5) : 999-1005. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.14-0628
dc.identifier.issn0002-9637
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183890
dc.description.abstractStudies on serotype-specific features of dengue and disease severity on adults are limited. We prospectively recruited adult febrile patients without alternate diagnosis to dengue from April 2005 to December 2011. Outcomes were defined using both the World Health Organization (WHO) 1997 and 2009 criteria; Dengue hemorrhagic fever (DHF) and severe dengue (SD). Infecting serotype was identified in 469 dengue-confirmed patients comprising 22.0% dengue virus serotype 1 (DENV-1), 57.1% DENV-2, 17.1% DENV-3, and 3.8% DENV-4. Cases infected with DENV-1 were more likely to present with red eyes whereas presence of joint pain and lower platelet count was associated with DENV-2 cases. After adjusting for potential confounders, DENV-1 was associated with both DHF (adjusted Relative Risk [aRR] = 1.74) and SD (aRR = 2.1) whereas DENV-2 had a lower risk of DHF (aRR = 0.5). DENV-1 genotype 1 and DENV-2 cosmopolitan were the predominant genotypes identified. Infecting dengue serotype and possibly genotype may play an important role in disease severity among adult dengue patients in Singapore. Copyright © 2015 by The American Society of Tropical Medicine and Hygiene.
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectenvelope protein
dc.subjectnonstructural protein 1
dc.subjectvirus protein
dc.subjectvirus RNA
dc.subjectvirus antibody
dc.subjectabdominal pain
dc.subjectadult
dc.subjectaged
dc.subjectarthralgia
dc.subjectArticle
dc.subjectclinical feature
dc.subjectdengue
dc.subjectDengue virus
dc.subjectDengue virus 1
dc.subjectDengue virus 2
dc.subjectDengue virus 3
dc.subjectDengue virus 4
dc.subjectdisease severity
dc.subjectdrowsiness
dc.subjectfemale
dc.subjectfever
dc.subjectgenotype
dc.subjecthematocrit
dc.subjecthematological parameters
dc.subjecthuman
dc.subjectinfection risk
dc.subjectleukocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmucosal bleeding
dc.subjectoutcome assessment
dc.subjectprospective study
dc.subjectprotein blood level
dc.subjectreal time polymerase chain reaction
dc.subjectreverse transcription polymerase chain reaction
dc.subjectserotype
dc.subjectSingapore
dc.subjectspecies difference
dc.subjectsystolic blood pressure
dc.subjectthrombocyte count
dc.subjectworld health organization
dc.subjectadolescent
dc.subjectblood
dc.subjectclassification
dc.subjectcohort analysis
dc.subjectdengue
dc.subjectDengue virus
dc.subjectgenetics
dc.subjectimmunology
dc.subjectisolation and purification
dc.subjectmiddle aged
dc.subjectrisk
dc.subjectserotype
dc.subjectserotyping
dc.subjectSevere Dengue
dc.subjectseverity of illness index
dc.subjectvery elderly
dc.subjectvirology
dc.subjectyoung adult
dc.subjectDengue virus
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAntibodies, Viral
dc.subjectCohort Studies
dc.subjectDengue
dc.subjectDengue Virus
dc.subjectFemale
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectRisk
dc.subjectRNA, Viral
dc.subjectSerogroup
dc.subjectSerotyping
dc.subjectSevere Dengue
dc.subjectSeverity of Illness Index
dc.subjectSingapore
dc.subjectSpecies Specificity
dc.subjectYoung Adult
dc.typeArticle
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.4269/ajtmh.14-0628
dc.description.sourcetitleAmerican Journal of Tropical Medicine and Hygiene
dc.description.volume92
dc.description.issue5
dc.description.page999-1005
dc.published.statepublished
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