Please use this identifier to cite or link to this item:
https://doi.org/10.4269/ajtmh.14-0628
DC Field | Value | |
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dc.title | Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore | |
dc.contributor.author | Yung, C.-F | |
dc.contributor.author | Lee, K.-S | |
dc.contributor.author | Thein, T.-L | |
dc.contributor.author | Tan, L.-K | |
dc.contributor.author | Gan, V.C | |
dc.contributor.author | Wong, J.G.X | |
dc.contributor.author | Lye, D.C | |
dc.contributor.author | Ng, L.-C | |
dc.contributor.author | Leo, Y.-S | |
dc.date.accessioned | 2020-11-23T08:56:23Z | |
dc.date.available | 2020-11-23T08:56:23Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Yung, C.-F, Lee, K.-S, Thein, T.-L, Tan, L.-K, Gan, V.C, Wong, J.G.X, Lye, D.C, Ng, L.-C, Leo, Y.-S (2015). Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. American Journal of Tropical Medicine and Hygiene 92 (5) : 999-1005. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.14-0628 | |
dc.identifier.issn | 0002-9637 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/183890 | |
dc.description.abstract | Studies on serotype-specific features of dengue and disease severity on adults are limited. We prospectively recruited adult febrile patients without alternate diagnosis to dengue from April 2005 to December 2011. Outcomes were defined using both the World Health Organization (WHO) 1997 and 2009 criteria; Dengue hemorrhagic fever (DHF) and severe dengue (SD). Infecting serotype was identified in 469 dengue-confirmed patients comprising 22.0% dengue virus serotype 1 (DENV-1), 57.1% DENV-2, 17.1% DENV-3, and 3.8% DENV-4. Cases infected with DENV-1 were more likely to present with red eyes whereas presence of joint pain and lower platelet count was associated with DENV-2 cases. After adjusting for potential confounders, DENV-1 was associated with both DHF (adjusted Relative Risk [aRR] = 1.74) and SD (aRR = 2.1) whereas DENV-2 had a lower risk of DHF (aRR = 0.5). DENV-1 genotype 1 and DENV-2 cosmopolitan were the predominant genotypes identified. Infecting dengue serotype and possibly genotype may play an important role in disease severity among adult dengue patients in Singapore. Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. | |
dc.publisher | American Society of Tropical Medicine and Hygiene | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | envelope protein | |
dc.subject | nonstructural protein 1 | |
dc.subject | virus protein | |
dc.subject | virus RNA | |
dc.subject | virus antibody | |
dc.subject | abdominal pain | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | arthralgia | |
dc.subject | Article | |
dc.subject | clinical feature | |
dc.subject | dengue | |
dc.subject | Dengue virus | |
dc.subject | Dengue virus 1 | |
dc.subject | Dengue virus 2 | |
dc.subject | Dengue virus 3 | |
dc.subject | Dengue virus 4 | |
dc.subject | disease severity | |
dc.subject | drowsiness | |
dc.subject | female | |
dc.subject | fever | |
dc.subject | genotype | |
dc.subject | hematocrit | |
dc.subject | hematological parameters | |
dc.subject | human | |
dc.subject | infection risk | |
dc.subject | leukocyte count | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | mucosal bleeding | |
dc.subject | outcome assessment | |
dc.subject | prospective study | |
dc.subject | protein blood level | |
dc.subject | real time polymerase chain reaction | |
dc.subject | reverse transcription polymerase chain reaction | |
dc.subject | serotype | |
dc.subject | Singapore | |
dc.subject | species difference | |
dc.subject | systolic blood pressure | |
dc.subject | thrombocyte count | |
dc.subject | world health organization | |
dc.subject | adolescent | |
dc.subject | blood | |
dc.subject | classification | |
dc.subject | cohort analysis | |
dc.subject | dengue | |
dc.subject | Dengue virus | |
dc.subject | genetics | |
dc.subject | immunology | |
dc.subject | isolation and purification | |
dc.subject | middle aged | |
dc.subject | risk | |
dc.subject | serotype | |
dc.subject | serotyping | |
dc.subject | Severe Dengue | |
dc.subject | severity of illness index | |
dc.subject | very elderly | |
dc.subject | virology | |
dc.subject | young adult | |
dc.subject | Dengue virus | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Antibodies, Viral | |
dc.subject | Cohort Studies | |
dc.subject | Dengue | |
dc.subject | Dengue Virus | |
dc.subject | Female | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Prospective Studies | |
dc.subject | Risk | |
dc.subject | RNA, Viral | |
dc.subject | Serogroup | |
dc.subject | Serotyping | |
dc.subject | Severe Dengue | |
dc.subject | Severity of Illness Index | |
dc.subject | Singapore | |
dc.subject | Species Specificity | |
dc.subject | Young Adult | |
dc.type | Article | |
dc.contributor.department | DEPT OF MEDICINE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.4269/ajtmh.14-0628 | |
dc.description.sourcetitle | American Journal of Tropical Medicine and Hygiene | |
dc.description.volume | 92 | |
dc.description.issue | 5 | |
dc.description.page | 999-1005 | |
dc.published.state | published | |
Appears in Collections: | Staff Publications Elements |
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