Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijerph15061250
Title: Maternal serum and breast milk adiponectin: The association with infant adiposity development
Authors: Mohamad, M
Loy, S.L 
Lim, P.Y
Wang, Y
Soo, K.L
Mohamed, H.J.J
Keywords: adiponectin
leptin
adiponectin
ADIPOQ protein, human
biological marker
leptin
hormone
milk
obesity
pregnancy
protein
serum
abdominal circumference
adult
anthropometry
Article
birth weight
blood sampling
body weight
breast milk
female
first trimester pregnancy
gestational age
human
human cell
Malaysia
milk level
obesity
pregnancy outcome
pregnant woman
protein blood level
protein milk level
risk assessment
risk factor
second trimester pregnancy
sex difference
third trimester pregnancy
breast milk
childhood obesity
follow up
infant
male
maternal nutrition
metabolism
newborn
pathology
pregnancy
prenatal exposure
prospective study
regression analysis
Kelantan
Malaysia
West Malaysia
Adiponectin
Adiposity
Adult
Biomarkers
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Leptin
Malaysia
Male
Maternal Nutritional Physiological Phenomena
Milk, Human
Pediatric Obesity
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prenatal Exposure Delayed Effects
Prospective Studies
Regression Analysis
Risk Factors
Issue Date: 2018
Publisher: MDPI
Citation: Mohamad, M, Loy, S.L, Lim, P.Y, Wang, Y, Soo, K.L, Mohamed, H.J.J (2018). Maternal serum and breast milk adiponectin: The association with infant adiposity development. International Journal of Environmental Research and Public Health 15 (6) : 1250. ScholarBank@NUS Repository. https://doi.org/10.3390/ijerph15061250
Rights: Attribution 4.0 International
Abstract: The prevalence of childhood obesity is increasing at an alarming rate in Malaysia. Metabolic changes during pregnancy are critical to the development of infant adiposity, due to imbalanced adipokines production. Hence, we aimed to investigate the association of maternal serum and breast milk adipokines with infant adiposity development. The study was conducted from April 2010 until December 2012. A total of 155 healthy pregnant mothers aged 19 to 40 years were recruited during the first and second trimester in Kelantan, Malaysia. Data consisted of maternal sociodemographic details, anthropometry and clinical biochemistry analysis; and the infant’s anthropometry and feeding patterns. Maternal fasting serum and breast milk samples were analysed for adiponectin and leptin levels. Data collection was performed in the second and third trimester of pregnancy, and continued with follow-up visits at birth, two, six, and 12 months postpartum. Multiple linear regression (MLR) analyses were performed to examine the associations between maternal serum and breast milk adiponectin and leptin and infant adiposity development. MLR models showed that, in the first year, as maternal serum and breast milk adiponectin increased, infant weight, BMI-for-age Z scores and abdominal circumference significantly decreased (p < 0.05). Maternal serum and/or breast milk adiponectin was associated with first-year infant adiposity development. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Environmental Research and Public Health
URI: https://scholarbank.nus.edu.sg/handle/10635/183839
ISSN: 1661-7827
DOI: 10.3390/ijerph15061250
Rights: Attribution 4.0 International
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