Please use this identifier to cite or link to this item:
https://doi.org/10.1001/jamapsychiatry.2018.1668
DC Field | Value | |
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dc.title | Longitudinal cognitive changes in young individuals at ultrahigh risk for psychosis | |
dc.contributor.author | Lam, M | |
dc.contributor.author | Lee, J | |
dc.contributor.author | Rapisarda, A | |
dc.contributor.author | See, Y.M | |
dc.contributor.author | Yang, Z | |
dc.contributor.author | Lee, S.-A | |
dc.contributor.author | Abdul-Rashid, N.A | |
dc.contributor.author | Kraus, M | |
dc.contributor.author | Subramaniam, M | |
dc.contributor.author | Chong, S.-A | |
dc.contributor.author | Keefe, R.S.E | |
dc.date.accessioned | 2020-11-23T08:46:45Z | |
dc.date.available | 2020-11-23T08:46:45Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Lam, M, Lee, J, Rapisarda, A, See, Y.M, Yang, Z, Lee, S.-A, Abdul-Rashid, N.A, Kraus, M, Subramaniam, M, Chong, S.-A, Keefe, R.S.E (2018). Longitudinal cognitive changes in young individuals at ultrahigh risk for psychosis. JAMA Psychiatry 75 (9) : 929-939. ScholarBank@NUS Repository. https://doi.org/10.1001/jamapsychiatry.2018.1668 | |
dc.identifier.issn | 2168-622X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/183833 | |
dc.description.abstract | Importance: Cognitive deficits are a key feature of risk for psychosis. Longitudinal changes in cognitive architecture may be associated with the social and occupational functioning in young people. Objectives: To examine longitudinal profiles of cognition in individuals at ultrahigh risk (UHR) for psychosis, compared with healthy controls, and to investigate the association of cognition with functioning. Design, Setting, and Participants: This study has a multiple-group prospective design completed in 24 months and was conducted from January 1, 2009, to November 11, 2012, as part of the Longitudinal Youth at-Risk Study conducted in Singapore. Participants either were recruited from psychiatric outpatient clinics, educational institutions, and community mental health agencies or self-referred. Follow-up assessments were performed every 6 months for 2 years or until conversion to psychosis. Individuals with medical causes for psychosis, current illicit substance use, or color blindness were excluded. Data analysis was conducted from June 2014 to May 2018. Main Outcomes and Measures: Neuropsychological, perceptual, and social cognitive tasks; semi-structured interviews, and the Structured Clinical Interview for DSM-IV Axis I disorders were administered every 6 months. The UHR status of nonconverters, converters, remitters, and nonremitters was monitored. Cognitive domain scores and functioning were investigated longitudinally. Results: In total, 384 healthy controls and 173 UHR individuals between ages 14 and 29 years were evaluated prospectively. Of the 384 healthy controls, 153 (39.8%) were female and 231 (60.2%) were male with a mean (SD) age of 21.69 (3.26) years. Of the 173 individuals at UHR for psychosis, 56 (32.4%) were female and 117 (67.6%) were male with a mean (SD) age of 21.27 (3.52) years). After 24 months of follow-up, 383 healthy controls (99.7%) and 122 individuals at UHR for psychosis (70.5%) remained. Baseline cognitive deficits were associated with psychosis conversion later (mean odds ratio [OR], 1.66; combined 95%CI, 1.08-2.83; P = .04) and nonremission of UHR status (mean OR, 1.67; combined 95%CI, 1.09-2.95; P = .04). Five cognitive components-social cognition, attention, verbal fluency, general cognitive function, and perception-were obtained from principal components analysis. Longitudinal component structure change was observed in general cognitive function (maximum vertical deviation = 0.59; ?2 = 8.03; P = .01). Group-by-time interaction on general cognitive function (F = 12.23; ?2 = 0.047; P < .001) and perception (F = 8.33; ?2 = 0.032; P < .001) was present. Changes in attention (F = 5.65; ?2 = 0.013; P = .02) and general cognitive function (F = 7.18; ?2 = 0.014; P = .01) accounted for longitudinal changes in social and occupational functioning. Conclusions and Relevance: Individuals in this study who met the UHR criteria appeared to demonstrate cognitive deficits, and those whose UHR status remitted were seen to recover cognitively. Cognition appeared as poor in nonremitters and appeared to be associated with poor functional outcome. This study suggests that cognitive dimensions are sensitive to the identification of young individuals at risk for psychosis and to the longitudinal course of those at highest risk. © 2018 American Medical Association. All rights reserved. | |
dc.publisher | American Medical Association | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | adolescent | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | attention | |
dc.subject | Beck Anxiety Inventory | |
dc.subject | Calgary Depression Scale | |
dc.subject | clinical evaluation | |
dc.subject | cognition | |
dc.subject | cognitive defect | |
dc.subject | color blindness | |
dc.subject | community mental health | |
dc.subject | controlled study | |
dc.subject | DSM-IV | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | high risk population | |
dc.subject | human | |
dc.subject | longitudinal study | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | odds ratio | |
dc.subject | outpatient department | |
dc.subject | perception | |
dc.subject | Positive and Negative Syndrome Scale | |
dc.subject | principal component analysis | |
dc.subject | prospective study | |
dc.subject | psychosis | |
dc.subject | risk assessment | |
dc.subject | school | |
dc.subject | semi structured interview | |
dc.subject | Singapore | |
dc.subject | Social and Occupational Functioning Assessment Scale | |
dc.subject | social cognition | |
dc.subject | Structured Clinical Interview for DSM Disorders | |
dc.subject | substance use | |
dc.subject | verbal memory | |
dc.subject | young adult | |
dc.subject | cognitive defect | |
dc.subject | Diagnostic and Statistical Manual of Mental Disorders | |
dc.subject | mental disease | |
dc.subject | neuropsychological test | |
dc.subject | procedures | |
dc.subject | psychological interview | |
dc.subject | psychological rating scale | |
dc.subject | psychology | |
dc.subject | psychosis | |
dc.subject | risk assessment | |
dc.subject | risk factor | |
dc.subject | social behavior | |
dc.subject | Adolescent | |
dc.subject | Cognition | |
dc.subject | Cognitive Dysfunction | |
dc.subject | Diagnostic and Statistical Manual of Mental Disorders | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Interview, Psychological | |
dc.subject | Longitudinal Studies | |
dc.subject | Male | |
dc.subject | Neuropsychological Tests | |
dc.subject | Psychiatric Status Rating Scales | |
dc.subject | Psychopathology | |
dc.subject | Psychotic Disorders | |
dc.subject | Risk Assessment | |
dc.subject | Risk Factors | |
dc.subject | Singapore | |
dc.subject | Social Behavior | |
dc.subject | Young Adult | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1001/jamapsychiatry.2018.1668 | |
dc.description.sourcetitle | JAMA Psychiatry | |
dc.description.volume | 75 | |
dc.description.issue | 9 | |
dc.description.page | 929-939 | |
dc.published.state | published | |
Appears in Collections: | Staff Publications Elements |
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