Please use this identifier to cite or link to this item: https://doi.org/10.1038/npjschz.2015.16
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dc.titleVoxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry
dc.contributor.authorCheng, W
dc.contributor.authorPalaniyappan, L
dc.contributor.authorLi, M
dc.contributor.authorKendrick, K.M
dc.contributor.authorZhang, J
dc.contributor.authorLuo, Q
dc.contributor.authorLiu, Z
dc.contributor.authorYu, R
dc.contributor.authorDeng, W
dc.contributor.authorWang, Q
dc.contributor.authorMa, X
dc.contributor.authorGuo, W
dc.contributor.authorFrancis, S
dc.contributor.authorLiddle, P
dc.contributor.authorMayer, A.R
dc.contributor.authorSchumann, G
dc.contributor.authorLi, T
dc.contributor.authorFeng, J
dc.date.accessioned2020-11-19T09:45:37Z
dc.date.available2020-11-19T09:45:37Z
dc.date.issued2015
dc.identifier.citationCheng, W, Palaniyappan, L, Li, M, Kendrick, K.M, Zhang, J, Luo, Q, Liu, Z, Yu, R, Deng, W, Wang, Q, Ma, X, Guo, W, Francis, S, Liddle, P, Mayer, A.R, Schumann, G, Li, T, Feng, J (2015). Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry. npj Schizophrenia 1 : 15016. ScholarBank@NUS Repository. https://doi.org/10.1038/npjschz.2015.16
dc.identifier.issn2334265X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183762
dc.description.abstractBackground: Wernicke's concept of 'sejunction' or aberrant associations among specialized brain regions is one of the earliest hypotheses attempting to explain the myriad of symptoms in psychotic disorders. Unbiased data mining of all possible brain-wide connections in large data sets is an essential first step in localizing these aberrant circuits. Methods: We analyzed functional connectivity using the largest resting-state neuroimaging data set reported to date in the schizophrenia literature (415 patients vs. 405 controls from UK, USA, Taiwan, and China). An exhaustive brain-wide association study at both regional and voxel-based levels enabled a continuous data-driven discovery of the key aberrant circuits in schizophrenia. Results: Results identify the thalamus as the key hub for altered functional networks in patients. Increased thalamus-primary somatosensory cortex connectivity was the most significant aberration in schizophrenia (P=10-18). Overall, a number of thalamic links with motor and sensory cortical regions showed increased connectivity in schizophrenia, whereas thalamo-frontal connectivity was weakened. Network changes were correlated with symptom severity and illness duration, and support vector machine analysis revealed discrimination accuracies of 73.53-80.92%. Conclusions: Widespread alterations in resting-state thalamocortical functional connectivity is likely to be a core feature of schizophrenia that contributes to the extensive sensory, motor, cognitive, and emotional impairments in this disorder. Changes in this schizophrenia-associated network could be a reliable mechanistic index to discriminate patients from healthy controls. @ 2015 Schizophrenia International Research Group/Nature Publishing Group.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectadult
dc.subjectalgorithm
dc.subjectArticle
dc.subjectbrain region
dc.subjectbrain wide association study
dc.subjectcaudate nucleus
dc.subjectChina
dc.subjectcognition
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectemotion
dc.subjectfemale
dc.subjectfunctional magnetic resonance imaging
dc.subjectglobus pallidus
dc.subjecthuman
dc.subjectinferior frontal gyrus
dc.subjectleft handedness
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle frontal gyrus
dc.subjectmotor performance
dc.subjectnuclear magnetic resonance scanner
dc.subjectpostcentral gyrus
dc.subjectprimary somatosensory cortex
dc.subjectpriority journal
dc.subjectputamen
dc.subjectresting state network
dc.subjectreward
dc.subjectright handedness
dc.subjectschizophrenia
dc.subjectsuperior frontal gyrus
dc.subjectsupport vector machine
dc.subjectTaiwan
dc.subjectthalamocortical tract
dc.subjectthalamofrontal tract
dc.subjectthalamus
dc.subjectUnited Kingdom
dc.subjectUnited States
dc.typeArticle
dc.contributor.departmentDEPT OF PSYCHOLOGY
dc.description.doi10.1038/npjschz.2015.16
dc.description.sourcetitlenpj Schizophrenia
dc.description.volume1
dc.description.page15016
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