Please use this identifier to cite or link to this item: https://doi.org/10.1098/rsfs.2015.0012
DC FieldValue
dc.titleEvolution of cubic membranes as antioxidant defence system
dc.contributor.authorDeng, Y
dc.contributor.authorAlmsherqi, Z.A
dc.date.accessioned2020-11-19T09:45:23Z
dc.date.available2020-11-19T09:45:23Z
dc.date.issued2015
dc.identifier.citationDeng, Y, Almsherqi, Z.A (2015). Evolution of cubic membranes as antioxidant defence system. Interface Focus 5 (4). ScholarBank@NUS Repository. https://doi.org/10.1098/rsfs.2015.0012
dc.identifier.issn20428898
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183761
dc.description.abstractPossibly the best-characterized cubic membrane transition has been observed in the mitochondrial inner membranes of free-living giant amoeba (Chaos carolinense). In this ancient organism, the cells are able to survive in extreme environments such as lack of food, thermal and osmolarity fluctuations and high levels of reactive oxygen species. Their mitochondrial inner membranes undergo rapid changes in three-dimensional organization upon food depletion, providing a valuable model to study this subcellular adaptation. Our data show that cubic membrane is enriched with unique ether phospholi-pids, plasmalogens carrying very long-chain polyunsaturated fatty acids. Here, we propose that these phospholipids may not only facilitate cubic membrane formation but mayalso provideaprotective sheltertoRNA. The potential inter-actionofcubic membranewithRNA may reduce the amountofRNA oxidation and promote more efficient protein translation. Thus, recognizing the role of cubic membranes in RNA antioxidant systems might help us to understand the adaptive mechanisms that have evolved over time in eukaryotes. @ 2015 The Authors.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.1098/rsfs.2015.0012
dc.description.sourcetitleInterface Focus
dc.description.volume5
dc.description.issue4
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