Please use this identifier to cite or link to this item: https://doi.org/10.1155/2016/1028945
Title: Blood glucose fluctuations in type 2 diabetes patients treated with multiple daily injections
Authors: Li, F.-F
Fu, L.-Y
Zhang, W.-L
Su, X.-F
Wu, J.-D
Sun, J
Ye, L 
Ma, J.-H
Keywords: insulin aspart
insulin glargine
antidiabetic agent
biological marker
biphasic insulin
glucose blood level
insulin aspart
insulin aspart, insulin aspart protamine drug combination 30:70
insulin glargine
isophane insulin
adult
aged
Article
bedtime dosage
blood glucose monitoring
continuous subcutaneous insulin infusion
controlled study
drug dose reduction
drug dose titration
female
glucose blood level
glycemic control
human
insulin intensive therapy
insulin treatment
intensive care
intermethod comparison
major clinical study
male
metabolic regulation
multicenter study
multiple daily injection
non insulin dependent diabetes mellitus
oxidative stress
priority journal
randomized controlled trial
therapy effect
treatment duration
treatment outcome
blood
China
clinical trial
comparative study
Diabetes Mellitus, Type 2
drug administration
drug effects
glucose blood level
hospitalization
insulin infusion
metabolism
middle aged
pilot study
prospective study
subcutaneous drug administration
time factor
Adult
Aged
Biomarkers
Biphasic Insulins
Blood Glucose
China
Diabetes Mellitus, Type 2
Drug Administration Schedule
Female
Hospitalization
Humans
Hypoglycemic Agents
Infusions, Subcutaneous
Injections, Subcutaneous
Insulin Aspart
Insulin Glargine
Insulin Infusion Systems
Insulin, Isophane
Male
Middle Aged
Pilot Projects
Prospective Studies
Time Factors
Treatment Outcome
Issue Date: 2016
Citation: Li, F.-F, Fu, L.-Y, Zhang, W.-L, Su, X.-F, Wu, J.-D, Sun, J, Ye, L, Ma, J.-H (2016). Blood glucose fluctuations in type 2 diabetes patients treated with multiple daily injections. Journal of Diabetes Research 2016 : 1028945. ScholarBank@NUS Repository. https://doi.org/10.1155/2016/1028945
Rights: Attribution 4.0 International
Abstract: To compare blood glucose fluctuations in type 2 diabetes mellitus (T2DM) patients were treated using three procedures: insulin intensive therapy which is continuous subcutaneous insulin infusion (CSII), MDI3 (three injections daily), and MDI4 (four injections daily). T2DM patients were hospitalized and were randomly assigned to CSII, aspart 30-based MDI3, and glargine based MDI4. Treatments were maintained for 2-3 weeks after the glycaemic target was reached. After completing the baseline assessment, 6-day continuous glucose monitoring (CGM) was performed before and after completion of insulin treatment. Treatment with CSII provided a greater improvement of blood glucose fluctuations than MDI (MDI3 or MDI4) therapy either in newly diagnosed or in long-standing T2DM patients. In long-standing diabetes patients, the MDI4 treatment group had significantly greater improvement of mean amplitude glycemic excursion (MAGE) than the MDI3 treatment group. However, in patients with newly diagnosed diabetes, there were no significant differences in the improvement of MAGE between MDI3 and MDI4 groups. Glargine based MDI4 therapy provided better glucose fluctuations than aspart 30-based MDI3 therapy, especially in long-standing T2DM patients, if CSII therapy was not available. @ 2016 Feng-fei Li et al.
Source Title: Journal of Diabetes Research
URI: https://scholarbank.nus.edu.sg/handle/10635/183727
ISSN: 23146745
DOI: 10.1155/2016/1028945
Rights: Attribution 4.0 International
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