Please use this identifier to cite or link to this item: https://doi.org/doi.org/10.1016/j.dental.2018.09.016
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dc.titleHydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi
dc.contributor.authorShruti Vidhawan Agarwalla
dc.contributor.authorKassapa Ellepola
dc.contributor.authorCALDEIRA FERRAZ DA COSTA, MARIANA
dc.contributor.authorGuilhermino José Macêdo Fechine
dc.contributor.authorMORIN, JULIEN LUC PAUL
dc.contributor.authorCASTRO NETO,ANTONIO HELIO
dc.contributor.authorChaminda Jayampath Seneviratne
dc.contributor.authorVINICIUS ROSA
dc.date.accessioned2020-11-16T04:37:40Z
dc.date.available2020-11-16T04:37:40Z
dc.date.issued2019-01-21
dc.identifier.citationShruti Vidhawan Agarwalla, Kassapa Ellepola, CALDEIRA FERRAZ DA COSTA, MARIANA, Guilhermino José Macêdo Fechine, MORIN, JULIEN LUC PAUL, CASTRO NETO,ANTONIO HELIO, Chaminda Jayampath Seneviratne, VINICIUS ROSA (2019-01-21). Hydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi. Dental Materials 35 (3) : 403-413. ScholarBank@NUS Repository. https://doi.org/doi.org/10.1016/j.dental.2018.09.016
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183442
dc.description.abstractObjective To evaluate the surface and wettability characteristics and the microbial biofilm interaction of graphene coating on titanium. Methods Graphene was deposited on titanium (Control) via a liquid-free technique. The transfer was performed once (TiGS), repeated two (TiGD) and five times (TiGV) and characterized by AFM (n = 10), Raman spectroscopy (n = 10), contact angle and SFE (n = 5). Biofilm formation (n = 3) to Streptococcus mutans, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans was evaluated after 24 h by CV assay, CFU, XTT and confocal microscopy. Statistics were performed by one-way Anova, Tukey’s tests and Pearson’s correlation analysis at a pre-set significance level of 5 %. Results Raman mappings revealed coverage yield of 82 % for TiGS and ≥99 % for TiGD and TiGV. Both TiGD and TiGV presented FWHM > 44 cm−1 and ID/IG ratio < 0.12, indicating multiple graphene layers and occlusion of defects. The contact angle was significantly higher for TiGD and TiGV (110° and 117°) comparing to the Control (70°). The SFE was lower for TiGD (13.8 mN/m) and TiGV (12.1 mN/m) comparing to Control (38.3 mN/m). TiGD was selected for biofilm assays and exhibited significant reduction in biofilm formation for all microorganisms compared to Control. There were statistical correlations between the high contact angle and low SFE of TiGD and decreased biofilm formation. Significance TiGD presented high quality and coverage and decreased biofilm formation for all species. The increased hydrophobicity of graphene films was correlated with the decreased biofilm formation for various species.
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S010956411830513X?via%3Dihub
dc.language.isoen
dc.publisherElsevier
dc.subjectPeri-implantitis
dc.subjectCoating
dc.subjectGraphene
dc.subjectInfection
dc.subjectImplants
dc.subjectCandida albicans, Streptococcus mutans, Pseudomonas aeruginosa, Biofilms, Glucosyltransferase, Dental caries
dc.typeArticle
dc.contributor.departmentCENTRE FOR ADVANCED 2D MATERIALS
dc.contributor.departmentDEPT OF DENTISTRY
dc.contributor.departmentDEPT OF PHYSICS
dc.description.doidoi.org/10.1016/j.dental.2018.09.016
dc.description.sourcetitleDental Materials
dc.description.volume35
dc.description.issue3
dc.description.page403-413
dc.published.statePublished
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