Please use this identifier to cite or link to this item: https://doi.org/https://doi.org/10.1016/j.jaip.2020.08.026
Title: Age-Related Differences in Immunological Responses to SARS-CoV-2
Authors: LYDIA WONG SU YIN 
LOO XIU LING,EVELYN 
KANG YI HUI, ALICIA 
Hui Xing Lau
PAUL ANANTHARAJAH TAMBYAH 
THAM HUIWEN ELIZABETH 
Keywords: COVID-19; Pediatric Multi-System Inflammatory Disorder; SARS-CoV-2
Issue Date: 13-Aug-2020
Publisher: The Journal of Allergy and Clinical Immunology: In Practice
Citation: LYDIA WONG SU YIN, LOO XIU LING,EVELYN, KANG YI HUI, ALICIA, Hui Xing Lau, PAUL ANANTHARAJAH TAMBYAH, THAM HUIWEN ELIZABETH (2020-08-13). Age-Related Differences in Immunological Responses to SARS-CoV-2. Journal of Allergy and Clinical Immunology: In Practice. ScholarBank@NUS Repository. https://doi.org/https://doi.org/10.1016/j.jaip.2020.08.026
Abstract: There is a striking age-related disparity in the prevalence and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 infections, which might be explained by age-dependent immunological mechanisms. These include age-related physiological differences in immunological responses, cross-neutralizing antibodies, and differences in levels and binding affinity of angiotensinconverting enzyme 2, the SARS-CoV-2 target receptor; antibodydependent enhancement in adults manifesting with an overexuberant systemic inflammation in response to infection; and the increased likelihood of comorbidities in adults and the elderly. Emerging immunological phenomena such as Pediatric Multi-System Inflammatory Disorder Temporally associated with SARS-CoV-2 or Multisystem Inflammatory Syndrome in Children are now being observed, though the underlying mechanisms are still unclear. Understanding the mechanisms through which pediatric patients are protected from severe novel coronaviruses infections will provide critical clues to the pathophysiology of coronavirus disease 2019 infection and inform future therapeutic and prophylactic interventions. Asymptomatic carriage in children may have major public health implications, which will have an impact on social and health care policies on screening and isolation practices, school reopening, and safe distancing requirements in the community.
Source Title: Journal of Allergy and Clinical Immunology: In Practice
URI: https://scholarbank.nus.edu.sg/handle/10635/183417
ISSN: 22132198
DOI: https://doi.org/10.1016/j.jaip.2020.08.026
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