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https://doi.org/10.1186/1465-9921-7-140
Title: | Airway inflammation contributes to health status in COPD: A cross-sectional study | Authors: | Snoeck-Stroband, J Postma, D.S Lapperre, T.S Gosman, M.M.E Thiadens, H.A Kauffman, H.F Sont, J.K Jansen, D.F Sterk, P.J |
Keywords: | methacholine adult aged article cell count chronic obstructive lung disease disease association disease severity female forced expiratory volume health status human hyperinflation inflammatory cell lung function major clinical study male multiple regression questionnaire respiratory tract inflammation scoring system smoking spirometry sputum examination univariate analysis comorbidity cross-sectional study epidemiology health status health status indicator immunology middle aged Netherlands pneumonia prevalence procedures Pulmonary Disease, Chronic Obstructive Respiratory Hypersensitivity risk assessment risk factor sputum Adult Causality Comorbidity Cross-Sectional Studies Female Health Status Health Status Indicators Humans Middle Aged Netherlands Pneumonia Prevalence Pulmonary Disease, Chronic Obstructive Respiratory Hypersensitivity Risk Assessment Risk Factors Sputum |
Issue Date: | 2006 | Citation: | Snoeck-Stroband, J, Postma, D.S, Lapperre, T.S, Gosman, M.M.E, Thiadens, H.A, Kauffman, H.F, Sont, J.K, Jansen, D.F, Sterk, P.J (2006). Airway inflammation contributes to health status in COPD: A cross-sectional study. Respiratory Research 7 : 140. ScholarBank@NUS Repository. https://doi.org/10.1186/1465-9921-7-140 | Rights: | Attribution 4.0 International | Abstract: | Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods: In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31-55] pack-years, no inhaled or oral corticosteroids, postbronchodilator FEV1: 63 ± 9% pred, FEV1/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator FEV1, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine (PC20). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results: Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and PC20 (B = -9.3, p = 0.024). Current smoking and FEV1, were not significantly associated with health status in the multiple regression analysis. Conclusion: We conclude that worse health status in COPID patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. © 2006 Snoeck-Stroband et al; licensee BioMed Central Ltd. | Source Title: | Respiratory Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/183286 | ISSN: | 14659921 | DOI: | 10.1186/1465-9921-7-140 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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