Please use this identifier to cite or link to this item: https://doi.org/10.1186/1532-429X-10-11
Title: Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment
Authors: He, T
Kirk, P
Firmin, D.N
Lam, W.M
Chu, W.C.W
Au, W.-Y
Chan, G.C.F
Tan, R.S 
Ng, I 
Biceroglu, S
Aydinok, Y
Fogel, M.A
Cohen, A.R
Pennell, D.J
Keywords: deferoxamine
iron
iron
adult
article
blood
breath holding
clinical article
clinical assessment
diagnostic value
heart muscle
human
iron overload
medical instrumentation
nuclear magnetic resonance
priority journal
reproducibility
thalassemia
United Kingdom
validation study
beta thalassemia
breathing
clinical trial
Hong Kong
instrumentation
metabolism
methodology
multicenter study
nuclear magnetic resonance imaging
observer variation
pathology
pathophysiology
prediction and forecasting
Singapore
Turkey (republic)
United States
Adult
beta-Thalassemia
Hong Kong
Humans
Iron
London
Magnetic Resonance Imaging
Myocardium
Observer Variation
Philadelphia
Predictive Value of Tests
Reproducibility of Results
Respiration
Singapore
Turkey
Issue Date: 2008
Citation: He, T, Kirk, P, Firmin, D.N, Lam, W.M, Chu, W.C.W, Au, W.-Y, Chan, G.C.F, Tan, R.S, Ng, I, Biceroglu, S, Aydinok, Y, Fogel, M.A, Cohen, A.R, Pennell, D.J (2008). Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. Journal of Cardiovascular Magnetic Resonance 10 (1) : 11. ScholarBank@NUS Repository. https://doi.org/10.1186/1532-429X-10-11
Rights: Attribution 4.0 International
Abstract: Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia. © 2008 Pennell; licensee BioMed Central Ltd.
Source Title: Journal of Cardiovascular Magnetic Resonance
URI: https://scholarbank.nus.edu.sg/handle/10635/183278
ISSN: 10976647
DOI: 10.1186/1532-429X-10-11
Rights: Attribution 4.0 International
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