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Title: | DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: A 27-year follow-up | Authors: | O'Donnell, K.J Chen, L MacIsaac, J.L McEwen, L.M Nguyen, T Beckmann, K Zhu, Y Chen, L.M Brooks-Gunn, J Goldman, D Grigorenko, E.L Leckman, J.F Diorio, J Karnani, N Olds, D.L Holbrook, J.D Kobor, M.S Meaney, M.J |
Keywords: | adult Article child abuse child neglect child parent relation childhood cohort analysis controlled study DNA methylation female follow up genetic variation genome human human experiment lifestyle male nurse perinatal period principal component analysis psychosocial environment risk reduction smoking adolescent Canada child abuse genetics home visit maternal child health care mental disease multifactorial inheritance nurse patient relationship perinatal care pregnancy prevention and control prospective study psychology risk factor young adult Adolescent Adult Canada Child Abuse DNA Methylation Female Follow-Up Studies House Calls Humans Maternal-Child Nursing Mental Disorders Multifactorial Inheritance Nurse-Patient Relations Perinatal Care Pregnancy Prospective Studies Risk Factors Young Adult |
Issue Date: | 2018 | Citation: | O'Donnell, K.J, Chen, L, MacIsaac, J.L, McEwen, L.M, Nguyen, T, Beckmann, K, Zhu, Y, Chen, L.M, Brooks-Gunn, J, Goldman, D, Grigorenko, E.L, Leckman, J.F, Diorio, J, Karnani, N, Olds, D.L, Holbrook, J.D, Kobor, M.S, Meaney, M.J (2018). DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: A 27-year follow-up. Translational Psychiatry 8 (1) : 63. ScholarBank@NUS Repository. https://doi.org/10.1038/s41398-017-0063-9 | Rights: | Attribution 4.0 International | Abstract: | This study reveals the influence of child maltreatment on DNA methylation across the genome and provides the first evidence that a psychosocial intervention program, the Nurse Family Partnership (NFP), which targets mothers at risk for abusive parenting, associates with variation in the DNA methylome in adult offspring. The 188 participants were born to women randomly assigned to control (n = 99) or nurse-visited intervention groups (n = 89) and provided blood samples and a diagnostic interview at age 27 years. Interindividual variation in the blood DNA methylome was described using principal components (PC) scores derived from principal component analysis and showed that the NFP program (PC10: p = 0.029) and a history of abuse/neglect (PC1: p = 0.029, PC2: p = 0.009) significantly associated with DNA methylome variation at 27 years of age independent of gender, ancestry, cellular heterogeneity, and a polygenic risk index for major psychiatric disorders. The magnitude of the association between child maltreatment and DNA methylation was reduced when accounting for lifestyle factors, including smoking. These findings reflect the sustained impact of both childhood adversity as well as intervention programs that target such adversity on the epigenome but highlight the need for prospective longitudinal studies of DNA methylome variation in the context of early intervention programs. © 2017 The Author(s). | Source Title: | Translational Psychiatry | URI: | https://scholarbank.nus.edu.sg/handle/10635/182069 | ISSN: | 21583188 | DOI: | 10.1038/s41398-017-0063-9 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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