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https://doi.org/10.18632/oncotarget.2482
Title: | Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation | Authors: | Tham, M Tan, K.W Keeble, J Wang, X Hubert, S Barron, L Tan, N.S Kato, M Prevost-Blondel, A Angeli, V Abastado, J.-P |
Keywords: | arginase CD34 antigen polyamine temozolomide transforming growth factor beta arginase transforming growth factor beta animal cell animal experiment animal model Article cancer cell cancer chemotherapy cancer growth cell proliferation cell stimulation cell survival controlled study female immunocompetent cell in vitro study in vivo study M2 macrophage macrophage male melanoma metastasis mouse nonhuman tumor associated leukocyte tumor initiating cell animal cancer stem cell cell proliferation cell survival disease model immunology macrophage melanoma metabolism mutant mouse strain pathology physiology signal transduction Animals Arginase Cell Proliferation Cell Survival Disease Models, Animal Female Macrophages Male Melanoma Mice Mice, Mutant Strains Neoplastic Stem Cells Signal Transduction Transforming Growth Factor beta |
Issue Date: | 2014 | Citation: | Tham, M, Tan, K.W, Keeble, J, Wang, X, Hubert, S, Barron, L, Tan, N.S, Kato, M, Prevost-Blondel, A, Angeli, V, Abastado, J.-P (2014). Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation. Oncotarget 5 (23) : 12027-12042. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.2482 | Rights: | Attribution 4.0 International | Abstract: | M2 macrophages promote tumor growth and metastasis, but their interactions with specific tumor cell populations are poorly characterized. Using a mouse model of spontaneous melanoma, we showed that CD34- but not CD34+ tumor-initiating cells (TICs) depend on M2 macrophages for survival and proliferation. Tumor-associated macrophages (TAMs) and macrophage-conditioned media protected CD34- TICs from chemotherapy in vitro. In vivo, while inhibition of CD115 suppressed the macrophagedependent CD34- TIC population, chemotherapy accelerated its development. The ability of TICs to respond to TAMs was acquired during melanoma progression and immediately preceded a surge in metastatic outgrowth. TAM-derived transforming growth factor-β (TGFβ) and polyamines produced via the Arginase pathway were critical for stimulation of TICs and synergized to promote their growth. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/181771 | ISSN: | 19492553 | DOI: | 10.18632/oncotarget.2482 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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